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178385

Apocynin

≥98% (GC), powder, NADPH oxidase inhibitor, Calbiochem®

Sinónimos:

Apocynin, 4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V

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Tamaño de envaseSKUDisponibilidadPrecio
1 g
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93,20 €

Acerca de este artículo

Fórmula empírica (notación de Hill):
C9H10O3
Número CAS:
Peso molecular:
166.17
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (GC)
Form:
powder
Storage condition:
OK to freeze, protect from light

93,20 €


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Nombre del producto

Apocynin, A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.

Quality Segment

description

Merck USA index - 14, 741

assay

≥98% (GC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white to brown

solubility

DMSO: 10 mg/mL, ethanol: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

O(C)c1c(ccc(c1)C(=O)C)O

InChI

1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3

InChI key

DFYRUELUNQRZTB-UHFFFAOYSA-N

General description

A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
NADPH oxidase
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Abid, M.R., et al. 2000. FEBS Lett.486, 252.
Muijsers, R.B., et al. 2000. Br. J. Pharmacol.130, 932.
Lapperre, T.S., et al. 1999. FEBS Lett.443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol.87, 776.
van der Goes, A., et al. 1998. J. Neuroimmunol.92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Este artículo
PHL83252A10809W508454
Apocynin phyproof® Reference Substance

PHL83252

Apocynin

form

powder

form

solid

form

powder

form

-

assay

≥98% (GC)

assay

≥95.0% (HPLC)

assay

98%

assay

≥98%

manufacturer/tradename

Calbiochem®

manufacturer/tradename

PhytoLab

manufacturer/tradename

-

manufacturer/tradename

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

300

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

-

solubility

DMSO: 10 mg/mL, ethanol: 20 mg/mL

solubility

-

solubility

-

solubility

-


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pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2



Certificados de análisis (COA)

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Número de artículo de comercio global

SKUGTIN
178385-1GM04055977222463

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