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09-774

Anti-EED Antibody

Name: Anti-EED Antibody
Brand: MM
Price: 556 EUR

from rabbit

Sinónimos:

embryonic ectoderm development

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Tamaño de envase	SKU	Disponibilidad	Precio
100 μg		Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	556,00 €

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UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

556,00 €

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Propiedades

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

species reactivity (predicted by homology)

dog, chicken, bovine, opossum, rat

technique(s)

western blot: suitable

NCBI accession no.

NP_003788

UniProt accession no.

O75530

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

dog ... Eed(476779)
human ... EED(8726)
mouse ... Eed(13626)
rat ... Eed(293104)

Descripción

General description

Polycomb group proteins are important for maintaining transcriptional silencing. One conserved PcG complex, PRC2, is composed of several proteins including the histone methyltransferase EZH2, the WD-repeat protein EED (Embryonic ectoderm development), and the Zn-finger protein Suz12. Transcriptional repression mediated by EED involves histone deacetylation, while the EZH2 methylates histone H3 on lysine 27. EED protein is present in four isoforms. These EED isoforms selectively associate with distinct EZH2-containing complexes, resulting in differential targeting of their associated methyltransferase activity. These complexes play a role in Hox gene silencing, X-inactivation, germline development, stem cell pluripotency and cancer metastasis.

~53 kDa observed. Uniprot describes three isoforms at 51 kDa (isoform 1), 53 kDa (isoform 2), and 46 kDa (isoform 3).

Immunogen

A synthetic peptide corresponding to a.a. 429-441 of human EED, conjugated to KLH.

Epitope: a.a. 429-441

Application

Use Anti-EED Antibody (Rabbit Polyclonal Antibody) validated in WB to detect EED also known as embryonic ectoderm development.

Biochem/physiol Actions

This antibody recognizes EED, Mr ~ 62-70 kDa.

Physical form

Format: Purified

Analysis Note

Control
Jurkat Cell Lysate

3T3/A31 cell lysate

Western Blot Analysis: 1 μg/mL of this lot detected EED on 10 μg of Jurkat cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: 09-727

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Este artículo	05-1320-M	03-196	07-1562
Sigma-Aldrich 09-774 Anti-EED Antibody	Sigma-Aldrich 05-1320-M Anti-EED Antibody, clone AA19	Sigma-Aldrich 03-196 RIPAb+ EED - RIP Validated Antibody and Primer Set	Sigma-Aldrich 07-1562 Anti-EZH2 Antibody
antibody form purified antibody	antibody form ascites fluid	antibody form purified antibody	antibody form serum
conjugate unconjugated	conjugate unconjugated	conjugate -	conjugate unconjugated
species reactivity human, mouse	species reactivity human, mouse	species reactivity human, mouse	species reactivity rat, mouse, human
clone polyclonal	clone monoclonal	clone monoclonal	clone polyclonal
biological source rabbit	biological source mouse	biological source mouse	biological source rabbit
technique(s) western blot: suitable	technique(s) western blot: suitable	technique(s) RIP: suitable, immunoprecipitation (IP): suitable, western blot: suitable	technique(s) western blot: suitable

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Ezh2 expression in astrocytes induces their dedifferentiation toward neural stem cells.

Falak Sher et al.

Cellular reprogramming, 13(1), 1-6 (2010-10-29)

Recently, we have demonstrated the expression of the polycomb group protein Ezh2 in embryonic and adult neural stem cells. Although Ezh2 remained highly expressed when neural stem cells differentiate into oligodendrocyte precursor cells, it is downregulated during the differentiation into

PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter.

Pinakin Pandya et al.

Cell death & disease, 10(10), 685-685 (2019-09-19)

Protein kinase C (PKC)-interacting cousin of thioredoxin (PICOT; also termed glutaredoxin 3 (Grx3; Glrx3)) is a ubiquitous protein that can interact with the embryonic ectoderm development (EED) protein via each of its two C-terminal PICOT/Grx homology domains. Since EED is

Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for non-small-cell lung cancer cells.

Taichi Takashina et al.

Cancer science, 107(7), 955-962 (2016-04-27)

Recent discoveries have revealed that human cancer involves aberrant epigenetic alterations. We and others have previously shown that the histone methyltransferase EZH2, the catalytic subunit of polycomb repressive complex 2 (PRC2), is frequently overexpressed in non-small-cell lung cancer (NSCLC) and