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07-810

Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody

Name: Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody
Brand: MM
Price: 428 EUR

Upstate^®, from rabbit

Sinónimos:

c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)

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Tamaño de envase	SKU	Disponibilidad	Precio
100 μL		Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	428,00 €

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UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Clone:

polyclonal

Species reactivity:

mouse, human

Application:

ICC, IF, WB

Citations:

428,00 €

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Propiedades

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

species reactivity (predicted by homology)

rat (based on 100% sequence homology)

manufacturer/tradename

Upstate^®

technique(s)

immunocytochemistry: suitable, immunofluorescence: suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_000245.2

UniProt accession no.

P08581

shipped in

dry ice

target post-translational modification

phosphorylation (pTyr1230/pTyr1234/pTyr1235)

Gene Information

human ... MET(4233)
mouse ... Met(17295)
rat ... Met(24553)

Descripción

General description

155 kDa

Immunogen

Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-c-Met (Tyr1230/Tyr1234/Tyr1235)

Application

Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody is an antibody against phospho-Met (Tyr1230/Tyr1234/Tyr1235) for use in IC, IF & WB.

Immunoblot Analysis: A 1:1000 dilution of this lot detected phospho-Met (Tyr1230/Tyr1234/Tyr1235) in RIPA lysate of HGF treated 293T cells.

Biochem/physiol Actions

Recognizes Met phosphorylated on both Tyr1234/Tyr1235 and Tyr1230/Tyr1234/Tyr1235.

Analysis Note

Routinely evaluated by immunoblot.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Este artículo	07-807	07-758	05-1049
Sigma-Aldrich 07-810 Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody	Sigma-Aldrich 07-807 Anti-phospho-Met (Tyr1003) Antibody	Sigma-Aldrich 07-758 Anti-phospho-Flt-1 (Tyr1213) Antibody	Sigma-Aldrich 05-1049 Anti-Met (extracellular) Antibody, clone 4F8.2
antibody form affinity purified immunoglobulin	antibody form affinity purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
clone polyclonal	clone polyclonal	clone polyclonal	clone 4F8.2, monoclonal
species reactivity mouse, human	species reactivity human	species reactivity bovine, human, goat, sheep, rat, mouse	species reactivity human
UniProt accession no. P08581	UniProt accession no. P08581	UniProt accession no. P17948	UniProt accession no. P08581
Gene Information human ... MET(4233) mouse ... Met(17295) rat ... Met(24553)	Gene Information human ... MET(4233)	Gene Information bovine ... Flt1(503620) human ... FLT1(2321) mouse ... Flt1(14254) rat ... Flt1(54251)	Gene Information human ... MET(4233)

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

P Longati et al.

Oncogene, 9(1), 49-57 (1994-01-01)

The tyrosine kinase encoded by the MET proto-oncogene (p190MET) is the receptor for Hepatocyte Growth Factor/Scatter Factor (HGF/SF). Previous work has shown that autophosphorylation of p190MET enhances its enzymatic activity and that the major phosphorylation site is Tyr1235, located in

Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes.

Kwang-Hoon Song et al.

Hepatology (Baltimore, Md.), 46(6), 1993-2002 (2007-10-10)

Bile acid synthesis in the liver is regulated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1). Transcription of the CYP7A1 gene is inhibited by bile acids and cytokines. The rate of bile acid synthesis is reduced immediately after partial hepatectomy and

Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity.

Federica Chiara et al.

The Journal of biological chemistry, 278(31), 29352-29358 (2003-05-15)

The met oncogene, encoding the high affinity hepatocyte growth factor receptor, is the only known gene inherited in human cancer that is invariably associated with somatic duplication of the mutant locus. Intriguingly, mutated Met requires ligand stimulation in order to

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07-810	04053252740510

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