09-241

Anti-phospho JAK-2 (Tyr570) Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), tyrosine-protein kinase JAK2
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: rat, human, pig, horse
• reactividad de especies (predicha por homología): primate (based on 100% sequence homology), equine (based on 100% sequence homology), porcine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_004963
• Nº de acceso UniProt: O60674
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: phosphorylation (pTyr570)
• Información sobre el gen: human ... JAK2(3717)

Descripción

Descripción general

JAK-2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK-2. JAK-2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. Within the JAK-2 kinase domain, there is a region that has considerable sequence homology to the regulatory region of the insulin receptor.

Especificidad

This antibody recognizes JAK-2 when phosphorylated on Tyr570.

Inmunógeno

Epitope: Phosphorylated Tyr570

KLH-conjugated linear peptide corresponding to human JAK-2 phosphorylated at Tyr570.

Aplicación

Research Category
Signaling

Research Sub Category
Cytokines & Cytokine Receptors

This Anti-phospho JAK-2 (Tyr570) Antibody is validated for use in WB, WB, WB for the detection of phospho JAK-2 (Tyr570).

Calidad

Evaluated by Western Blot in transfected HEK293T cell lysates.

Western Blot Analysis: 0.05 ug/mL of this antibody detected JAK-2 on 10 µg of transfected HEK293T cell lysates.

Descripción de destino

~ 125 kDa

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
Transfected HEK293T cell lysates

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable