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P2363

Protein Kinase G II from rat

Name: Protein Kinase G II from rat
Brand: SIGMA

>90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, solution

Sinónimos:

Protein Kinase, 3′,5′-Cyclic GMP Dependent from rat

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UNSPSC Code:

41106305

NACRES:

NA.32

MDL number:

MFCD03444648

Specific activity:

~0.7 U/mg

Assay:

>90% (SDS-PAGE)

Recombinant:

expressed in baculovirus infected Sf9 cells

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Propiedades

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

assay

>90% (SDS-PAGE)

form

solution

specific activity

~0.7 U/mg

UniProt accession no.

Q64595

shipped in

dry ice

storage temp.

−20°C

Gene Information

rat ... Prkg2(25523)

Descripción

General description

Protein kinase, cGMP-dependent, type II (PRKG2), also known as type II cGMP-dependent protein kinase (cGK), is encoded by the gene mapped to human chromosome 4q13.1–q21.1.

Biochem/physiol Actions

Protein kinase, cGMP-dependent, type II (PRKG2) is implicated in the regulation of intestinal fluid balance in man. The encoded protein plays an essential role in proliferative to hypertrophic transition of growth plate chondrocytes during endochondral ossification. Loss of PRKG2 function is associated with the development of renal cysts, intellectual disability and speech defect. In rodent and bovine models, deletion of the gene leads to dwarfism.

Other Notes

One unit will phosphorylate one μmole of VASPtide (RRKVSKQE) per minute at pH 7.4

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Este artículo	P6998	P3738	C8482
Sigma-Aldrich P2363 Protein Kinase G II from rat	Sigma-Aldrich P6998 Protein Kinase A Catalytic Subunit β, Active human	Sigma-Aldrich P3738 Protein Kinase G Iβ human	Sigma-Aldrich C8482 Protein Kinase A catalytic subunit human
Gene Information rat ... Prkg2(25523)	Gene Information human ... PRKACB(5567)	Gene Information human ... PRKG1(5592)	Gene Information human ... PRKACA(5566)
assay >90% (SDS-PAGE)	assay ≥80% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay >90% (SDS-PAGE)
specific activity ~0.7 U/mg	specific activity ≥10 nmol/min·mg	specific activity ≥1.5 units/mg protein (20-fold stimulation by cGMP (5 μM))	specific activity >1000 units/mg protein
form solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in E. coli
UniProt accession no. Q64595	UniProt accession no. P22694	UniProt accession no. Q13976	UniProt accession no. P17612