Intensified and Continuous Downstream Processing
Gain operational efficiency and flexibility while reducing footprint and costs
Looking to increase your downstream process efficiency?
Transformation of the biomanufacturing workflow is being accelerated by the demand for new therapeutics combined with the need to reduce costs while ensuring operational flexibility and productivity.
Process intensification, closed, and continuous bioprocessing are foundational strategies for achieving these goals. They are widely and successfully deployed in the downstream suite to be more efficient, faster, smaller, less expensive, and sustainable.
To help biopharmaceutical manufacturers intensify, closing, digitally-enhance, or go fully continuous with their processes and gain new levels of operational efficiency and flexibility, there are multiple levers within the DSP suite.
Procesamiento downstream (DSP) intensificado y continuo
Procesamiento downstream (DSP) intensificado y continuo
No matter your path – developing an intensified or continuous bioprocess we provide advanced downstream process technologies to help you achieve your purification goals.
Categorías relacionadas
Los sistemas de cromatografía de un solo uso y de múltiples usos son fundamentales para la separación de sus valiosas moléculas.
La cromatografía de afinidad suele utilizarse durante la fase de captura para aislar la molécula deseada y reducir el volumen del proceso.
La cromatografía de intercambio iónico (IEX) separa las biomoléculas en función de la diferencia de carga entre la molécula específica y la resina cromatográfica.
Optimize downstream purification using membrane chromatography for capture and polishing. Natrix membranes boost economics and facility efficiency.
Elevate Filtration Precision: Our tangential flow products ensure purity for mAbs, vaccines, and more, scaling from single-use to multi-use.
Recursos relacionados
- What is Multi Column Chromatography?
In this article, we will discuss one of the methods used to intensify the capture chromatography process: multi column chromatography (MCC).
- Mobius® Multi Column Capture System
The Mobius® Multi Column Capture system is designed as a fully automated, single-use solution to operate continuous closed capture chromatography.
- App Note: Multi Column Capture
Results from the multi-column capture (MCC) system implementation as part of a fully integrated downstream continuous manufacturing platform are reported here.
- Intensified Polishing Using Single-Pass Tangential Flow Filtration (SPTFF) with Anion Exchange Chromatography
In this app note, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity.
- Brochure: Process Development and Drug Manufacturing: Support Services
We provide comprehensive services for drug development and manufacturing, including technical and regulatory expertise and process development support.
- Article: pDADMAC Flocculation in Monoclonal Antibody Production Processes – Overcoming Regulatory Challenges with Quality Risk Management
Flocculants, like pDADMAC, remove cell debris during downstream monoclonal antibody production, but their adoption has been difficult due to perceived regulatory concerns.
Seminarios virtuales relacionados
Improve your process efficiency and reduce costs
Vídeos relacionados
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