F5053

Flavin-Containing Monooxygenase-3, Microsomes human

recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution

• Sinónimos: FMO-3
• Número CE: 1.14.13.8 (BRENDA, IUBMB)
• NACRES: NA.54
• UNSPSC Code: 12352204
• Recombinant: expressed in baculovirus infected insect cells

Propiedades

• recombinant: expressed in baculovirus infected insect cells
• Quality Level: 200
• form: buffered aqueous solution
• mol wt: 55-60 kDa
• packaging: vial of 2.5 mg
• UniProt accession no.: P31513
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... FMO3(2328)

Descripción

General description

Flavin-Containing Monooxygenase-3 (FMO3) is a member of the flavin-containing monooxygenase (FMO) family of enzymes. It is highly expressed in the human liver.[1]

Application

FMO3 is the major human hepatic form.

Biochem/physiol Actions

Flavin-Containing Monooxygenase-3 (FMO3) facilitates the oxidization of several drugs, chemicals, and xenobiotics.[2] Human FMO3 is also involved in the synthesis of N-oxide of trimethylamine (TMAO) from trimethylamine (TMA).[3] Mutations in the FMO3 gene are associated with trimethylaminuria or fish odor syndrome.[1][4] Deficiency of the FMO3 gene results in lower plasma TMAO levels, which may reduce the risk of developing atherosclerosis and thrombosis.[4]

Physical form

Solution in 100 mM potassium phosphate buffer, pH 7.4

Información de seguridad

• Clase de almacenamiento: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)