The chemicals encyclopedia published by the Royal Society of Chemistry (11th ed., entry #2939) reports a melting point of 217-218°C.
D9302
Diacerein
≥95% (HPLC)
Sinónimos:
1,8-Diacetoxy-3-carboxyanthraquinone
Iniciar sesión para ver los precios por organización y contrato.
Acerca de este artículo
Fórmula empírica (notación de Hill):
C19H12O8
Número CAS:
Peso molecular:
368.29
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
237-310-2
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
assay
≥95% (HPLC)
form
powder
SMILES string
CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(C)=O)c3C(=O)c12)C(O)=O
InChI
1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)
InChI key
TYNLGDBUJLVSMA-UHFFFAOYSA-N
Biochem/physiol Actions
Diacerin is an inhibitor of Interleukin-1B (IL-1B) production.
1 of 1
Este artículo | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay - | assay ≥96.5% (GC), 97% | assay - |
| form powder | form solid | form liquid | form - |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
E M Bartels et al.
Osteoarthritis and cartilage, 18(3), 289-296 (2009-10-28)
To estimate the efficacy and safety of diacerein as a pain-reducing agent in the treatment of osteoarthritis (OA), using meta-analysis of published randomized placebo-controlled trials (RCTs). Systematic searches of the bibliographic databases Medline, Embase, Cinahl, Chemical Abstracts, Cochrane and Web
Vinícius Maria Gadotti et al.
Pharmacology, biochemistry, and behavior, 102(4), 549-554 (2012-07-04)
The present study evaluated the antinociceptive effect of the pro-inflammatory cytokines inhibitor diacerein in mice and its possible mechanism of action. The antinociception produced by diacerein was tested at different sites of action, moreover selective antagonists or agonists were used
Ballari Brahmachari et al.
Clinical rheumatology, 28(10), 1193-1198 (2009-07-15)
The objective of this study was to evaluate the efficacy and safety of diacerein in early, symptomatic knee osteoarthritis in Indian population. Sixty-four patients of knee osteoarthritis fulfilling American College of Rheumatology Criteria were randomized to receive either diacerein or
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| D9302-50MG | 04061833590591 |
-
What is the melting point of Product D9302, Diacerein?
1 answer-
Helpful?
-
-
Can Product D9302, Diacerein, be dissolved in DMSO?
1 answer-
Yes. Diacerein is soluble in DMSO at 1 mg/mL. The compound is also soluble in acetic acid at a concentration of 25 mg in 8 mL, as stated on the specification sheet.
Helpful?
-
-
What is the biological activity of Product D9302, Diacerein?
1 answer-
Martindale, 30th ed. indicates that "Diacerein is a non-steroidal anti-inflammatory agent that has been used in musculoskeletal and joint disorders." Diacerein acts by inhibiting interleukin-1. The chemicals encyclopedia published by the Royal Society of Chemistry, 11th ed., indicates that Diacerein "demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis".
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-
-
What is the mechanism of action of Product D9302, Diacerein?
1 answer-
"Diacerein is a slow acting symptomatic treatment of osteoarthritis which has demonstrated efficacy on functional manifestations of osteoarthritis and on the structural component. Two mechanisms of action have been validated: in vitro inhibition of interleukin-1 (IL-1) synthesis, the main cytokine involved in cartilage destruction, and activity on the synthesis of proteoglycans, and hyaluronic acid, the principal component of cartilage. Other studies presented here have provided further details concerning other mechanisms of action of diacerein", according to Presse Med., 33(9 Pt 2), S10-S12 (2004).
Helpful?
-