D7145

2′-Deoxyguanosine monohydrate

99-100%, synthetic (organic), powder

• Sinónimos: 2′-Deoxyguanosine hydrate, 9-(2-Deoxy-β-D-ribofuranosyl)guanine, Guanine-2′-deoxyriboside
• Fórmula empírica (notación de Hill): C₁₀H₁₃N₅O₄ · H₂O
• Número CAS: 312693-72-4
• Peso molecular: 285.26
• NACRES: NA.51
• PubChem Substance ID: 24894083
• UNSPSC Code: 41106305
• MDL number: MFCD00150760
• Beilstein/REAXYS Number: 39814
• Assay: 99-100%
• Biological source: synthetic (organic)
• Form: powder
• Solubility: 1 M NH₄OH: 50 mg/mL, clear, colorless

Propiedades

• Nombre del producto: 2′-Deoxyguanosine monohydrate, 99-100%
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: 99-100%
• form: powder
• solubility: 1 M NH₄OH: 50 mg/mL, clear, colorless
• SMILES string: O.NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1
• InChI: 1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1
• InChI key: LZSCQUCOIRGCEJ-FPKZOZHISA-N

Descripción

Application

2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:

• to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish[1],
• in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis[2],
• in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes[3]

Biochem/physiol Actions

Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphorylation (kinases) forms deoxyguanosine triphosphate (dGTP) which is used by DNA polymerases and reverse transcriptases to synthesize DNA(s).[4] Deoxyguanosine is the most electron-rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage.[5] This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.[6]

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable