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C271

CX546

Name: CX546
Brand: SIGMA

≥98% (HPLC), solid

Sinónimos:

1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine

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Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₄H₁₇NO₃

Número CAS:

215923-54-9

Peso molecular:

247.29

NACRES:

NA.77

PubChem Substance ID:

24277960

UNSPSC Code:

12352200

MDL number:

MFCD01860868

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white to off-white

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

O=C(N1CCCCC1)c2ccc3OCCOc3c2

InChI

1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2

InChI key

LJUNPHMOGNFFOS-UHFFFAOYSA-N

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Este artículo	HPA014821	SML1191	SML0314
Sigma-Aldrich C271 CX546	Sigma-Aldrich HPA014821 Anti-GJA3 antibody produced in rabbit	Sigma-Aldrich SML1191 CX516	Sigma-Aldrich SML0314 CGP77675
assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form buffered aqueous glycerol solution	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition protect from light	storage condition -	storage condition -	storage condition -
solubility DMSO: ≥10 mg/mL	solubility -	solubility H₂O: 5 mg/mL, clear	solubility DMSO: >10 mg/mL

General description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.[1]

Application

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

Biochem/physiol Actions

Positive AMPA glutamate receptor modulator.

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

Disclaimer

Photosensitive

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.

Amy C Arai et al.

The Journal of pharmacology and experimental therapeutics, 303(3), 1075-1085 (2002-11-20)

CX516 (BDP-12) and CX546, two first-generation benzamide-type AMPA receptor modulators, were compared with regard to their influence on AMPA receptor-mediated currents, autaptic responses in cultured hippocampal neurons, hippocampal excitatory postsynaptic currents, synaptic field potentials, and agonist binding. The two drugs

Positive Modulation of AMPA Receptors Promotes Survival and Proliferation of Neural Stem/Progenitor Cells from the Adult Rat Spinal Cord.

Laureen D Hachem et al.

Stem cells and development, 26(23), 1675-1681 (2017-09-28)

Transplantation of neural stem/progenitor cells (NSPCs) following spinal cord injury (SCI) is a promising strategy to enhance regeneration but is limited by poor survival of grafted cells. Determining methods to enhance survival of NSPCs is therefore essential. Positive modulation of

Ampakine? CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators

Pellerin L and Magistretti PJ

Journal of Neurochemistry, 92(3), 668-677 (2005)

Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex.

Hiroaki Sacai et al.

Nature communications, 11(1), 5140-5140 (2020-10-14)

Autism spectrum disorder (ASD) is thought to result from deviation from normal development of neural circuits and synaptic function. Many genes with mutation in ASD patients have been identified. Here we report that two molecules associated with ASD susceptibility, contactin

Ampakines: Labelling with ¹¹C for PET distribution studies.

Rogers, et al.

Journal of Labelled Compounds & Radiopharmaceuticals, 40, 645-647 (1997)

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Número de artículo de comercio global

SKU	GTIN
C271-50MG	04061832081540
C271-10MG	04061832081533

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