B7777

Budesonide

≥99%

• Sinónimos: 16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
• Fórmula empírica (notación de Hill): C₂₅H₃₄O₆
• Número de CAS: 51333-22-3
• Peso molecular: 430.53
• Número CE: 257-139-7
• Número MDL: MFCD00083259
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278277
• NACRES: NA.77

Propiedades

• Ensayo: ≥99%
• Formulario: powder
• emisor: AstraZeneca
• cadena SMILES: [H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H]5OC(CCC)O[C@@]45C(=O)CO
• InChI: 1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
• Clave InChI: VOVIALXJUBGFJZ-KWVAZRHASA-N
• Información sobre el gen: human ... IFNG(3458) , IL5(3567) , NR3C1(2908) ; rat ... Nr3c1(24413)

Descripción

Acciones bioquímicas o fisiológicas

Budesonide is a second generation glucocorticoid with low systemic absorption. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis, and inflammatory bowel disease. It inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein in primary human bronchial epithelial cells. Budesonide is currently in clinical trials for the prevention of lung cancer. It shows inhibitory effects on benzo[a]pyrene-induced carcinogenesis of the lung in mice.

Second generation glucocorticoid with low systemic absorption; anti-inflammatory agent; inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein.

Características y beneficios

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302,H317,H361d,H372,H412
• Consejos de prudencia: P202 - P273 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - Skin Sens. 1 - STOT RE 1 Inhalation
• Órganos de actuación: Adrenal gland
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)