A7229
PUGNAc
≥95% (HPLC)
Sinónimos:
O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 5 mg | Comprobar disponibilidad del carrito | MXP 4,282.00 | |
| 10 mg | Comprobar disponibilidad del carrito | MXP 7,982.00 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C15H19N3O7
Número CAS:
Peso molecular:
353.33
UNSPSC Code:
12352204
NACRES:
NA.26
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4274031
Assay:
≥95% (HPLC)
Form:
crystals
MXP 4,282.00
Comprobar disponibilidad del carrito
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥95% (HPLC)
form
crystals
storage temp.
−20°C
SMILES string
CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O\C1=N/OC(=O)Nc2ccccc2
InChI
1S/C15H19N3O7/c1-8(20)16-11-13(22)12(21)10(7-19)24-14(11)18-25-15(23)17-9-5-3-2-4-6-9/h2-6,10-13,19,21-22H,7H2,1H3,(H,16,20)(H,17,23)/b18-14-/t10-,11-,12-,13-/m1/s1
InChI key
PBLNJFVQMUMOJY-JXZOILRNSA-N
Application
O-(2-acetamido-2deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) has been used to evaluate the effects of silibinin on O-GlcNAc levels of glycoproteins in Adult Retinal Pigment Epithelial-19 (ARPE-19) cells. It has also been used as a component of the HEPES lysis buffer for rat brain samples.
PUGNAc has been used as an inhibitor of O-GlcNAc-β-N-acetylglucosaminidase.[1]
Biochem/physiol Actions
PUGNAc is an in vitro and in vivo inhibitor of peptide O-GlcNAc-β-N-acetylglucosaminidase, the enzyme which removes O-linked N-acetylglucosamine (O-GlcNAc) from O-linked glycosylated proteins.
O-(2-acetamido-2deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) induces insulin resistance in 3T3-L1 adipocytes by reducing insulin-prompting phosphorylation of protein kinase B (Akt) and glycogen synthase kinase 3β (GSK3β).
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Este artículo | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥98% | assay ≥93% (HPLC) | assay ≥98% (TLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| form crystals | form powder | form powder | form powder |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes
Park S Y, et al.
Experimental & Molecular Medicine, 37(3), 220-220 (2005)
O-GlcNAc modification is associated with insulin sensitivity in the whole blood of healthy young adult males.
Myslicki JP, et al.
Diabetology & Metabolic Syndrome, 6, 96-96 (2014)
Matthew S Macauley et al.
Biochimica et biophysica acta, 1800(2), 107-121 (2009-08-12)
The O-GlcNAc modification is found on many nucleocytoplasmic proteins. The dynamic nature of O-GlcNAc, which in some ways is reminiscent of phosphorylation, has enabled investigators to modulate the stoichiometry of O-GlcNAc on proteins in order to study its function. Although
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| A7229-10MG | 04061833383841 |
| A7229-5MG | 04061833383858 |