A6933

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

≥97% (HPLC), powder

• Sinónimos: Ac-QKLVFF-NH₂, amyloid blocker
• Fórmula empírica (notación de Hill): C₄₂H₆₃N₉O₈
• Número CAS: 189064-06-0
• Peso molecular: 822.01
• NACRES: NA.32
• PubChem Substance ID: 329770908
• UNSPSC Code: 12352202
• MDL number: MFCD17215285
• Form: powder
• Assay: ≥97% (HPLC)

Propiedades

• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• color: white
• UniProt accession no.: P05067
• storage temp.: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(N)=O
• InChI: 1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1
• InChI key: DDXTVYDSGCHGAN-PITCCTKHSA-N
• Gene Information: human ... APP(351)

Descripción

Biochem/physiol Actions

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)