50838
(R)-Mevalonic acid lithium salt
≥93.0% (qNMR)
Sinónimos:
Lithium (R)-3,5-dihydroxy-3-methylpentanoate, Lithium (R)-3,5-dihydroxy-3-methylvalerate, R-MVA-Li
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C6H11LiO4
Número CAS:
Peso molecular:
154.09
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Assay:
≥93.0% (qNMR)
assay
≥93.0% (qNMR)
optical activity
[α]/D -26±3°, c = 0.1 in 0.1 M HCl (16 h)
storage temp.
2-8°C
SMILES string
[Li+].C[C@@](O)(CCO)CC([O-])=O
InChI
1S/C6H12O4.Li/c1-6(10,2-3-7)4-5(8)9;/h7,10H,2-4H2,1H3,(H,8,9);/q;+1/p-1/t6-;/m1./s1
InChI key
PVWNXFFXFNEHDZ-FYZOBXCZSA-M
Application
Mevalonic acid may be used as a reference material in assays for the separation or detection of mevalonic acid. Mevalonic acid is a precursor of isopentenyl pyrophosphate (IPP) and the mevalonate pathway which leads to isoprenoid biosynthesis. Mevalonic acid may be used as a substrate to identify and characterize mevalonate kinase(s).
Biochem/physiol Actions
Mevalonic acid, is an intermediate in the mevalonate pathway, producing terpenes and steroids. This function provides treatment options metabolic disorders[1] [2] [3][4][5], R-mevalonate accumulates in patients with the autosomal recessively inherited mevalonic acidurias, an inborn error of cholesterol and nonsterol isoprene biosynthesis[6].
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
1 of 1
Este artículo | |||
|---|---|---|---|
| assay ≥93.0% (qNMR) | assay ≥96.0% (GC) | assay ≥96.0% (GC) | assay ≥96.0% (GC) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
| optical activity [α]/D -26±3°, c = 0.1 in 0.1 M HCl (16 h) | optical activity - | optical activity [α]/D +25.0±3.0°, c = 0.1 in 1 M HCl | optical activity - |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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S M Houten et al.
Cellular and molecular life sciences : CMLS, 60(6), 1118-1134 (2003-07-16)
Mevalonate kinase (MK) is an essential enzyme in the isoprenoid biosynthesis pathway which produces numerous biomolecules (isoprenoids) involved in a variety of cellular processes. The indispensability of MK and isoprenoid biosynthesis for human health is demonstrated by the identification of
Irina Buhaescu et al.
Clinical biochemistry, 40(9-10), 575-584 (2007-05-01)
Mevalonate pathway is an important metabolic pathway which plays a key role in multiple cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol isoprenoids, such as dolichol, heme-A, isopentenyl tRNA and ubiquinone. While extensively studied in regard with
Dorothea Haas et al.
Orphanet journal of rare diseases, 1, 13-13 (2006-05-26)
Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) represent the two ends of a clinical spectrum of disease caused by deficiency of mevalonate kinase (MVK), the first committed enzyme of cholesterol biosynthesis. At least 30 patients with MVA and 180
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 50838-10MG | 04061832404486 |
| 50838-50MG | 04061832489483 |