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A115

Supelco

Amitriptyline metabolite, (±)-E-10-hydroxylated-

analytical standard

Sinónimos:

(±)-(E)-5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

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2 MG
MXP 6,549.00

MXP 6,549.00

Fecha estimada de envío29 de mayo de 2025

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2 MG
MXP 6,549.00

About This Item

Fórmula empírica (notación de Hill):
C20H23NO
Número de CAS:
64520-05-4
Peso molecular:
293.40
Número MDL:
MFCD00069200
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329770681
NACRES:
NA.24

MXP 6,549.00

Fecha estimada de envío29 de mayo de 2025

Solicitar un pedido a granel

grado

analytical standard

Nivel de calidad

200

Formulario

solid

técnicas

HPLC: suitable
gas chromatography (GC): suitable

color

white

mp

97-99 °C

solubilidad

0.1 M HCl: soluble
H2O: insoluble
methanol: soluble

aplicaciones

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

cadena SMILES

CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13

InChI

1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+

Clave InChI

GHWBJXOKAFHZAI-SFQUDFHCSA-N

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Aplicación

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Acciones bioquímicas o fisiológicas

Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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R T Coutts et al.
Xenobiotica; the fate of foreign compounds in biological systems, 27(1), 33-47 (1997-01-01)
1. Expressed human cytochrome P450 enzyme CPY2D6 was used to metabolize amitriptyline (AMI). It was established that CYP2D6 not only catalyzed ring 10-hydroxylation of AMI, but also mediated its N-demethylation to nortriptyline (NT), as well as the formation of 10-hydroxy-NT
E Nusser et al.
Journal of chromatography, 528(1), 163-171 (1990-06-08)
E- and Z-10-hydroxyamitriptyline (E- and Z-10-OH-AT) are racemic alcoholic metabolites of the antidepressant amitriptyline. Their enantiomers were separated by high-performance liquid chromatography as diastereomeric derivatives using R-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (Mosher's reagent). Although E-10-hydroxyamitriptyline excreted in patient urine in free form or
P Baumann et al.
International clinical psychopharmacology, 1(2), 102-112 (1986-04-01)
A subgroup of 16 out of 30 endogenous depressive inpatients (cf. part I), treated for 3 weeks with 150 mg amitriptyline (AT) daily, participated in a pharmacogenetic study: all were phenotyped with debrisoquine and 3 of them with mephenytoin. Four
K Shimoda et al.
Journal of clinical psychopharmacology, 15(3), 175-181 (1995-06-01)
We measured the concentrations in plasma of amitriptyline and its metabolites, nortriptyline and geometric isomers of 10-hydroxynortriptyline and 10-hydroxyamitriptyline, in 73 Japanese psychiatric patients receiving amitriptyline hydrochloride (Tryptanol; Banyu Pharmaceutical Co. Ltd., Tokyo, Japan) by high-performance liquid chromatography. Although there
F Coudoré et al.
Cell biology and toxicology, 13(2), 131-137 (1997-02-01)
Biotransformation of amitriptyline (AMI) was studied at different intervals in freshly isolated hepatocytes from healthy or streptozocin-induced diabetic rats in order to investigate the influence of the diabetic state. Levels of free and conjugated AMI, demethylated and hydroxylated metabolites, were
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