901534

(S,R,S)-AHPC-C₆-CO₂H hydrochloride

• Szinonimák: 7-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)heptanoic acid, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader, VH032 conjugate
• Tapasztalati képlet (Hill-képlet): C₂₉H₄₂N₄O₅S · xHCl
• Molekulatömeg: 558.73 (free base basis)
• MDL-szám: MFCD32062444
• UNSPSC kód: 12352101
• NACRES: NA.22
• Forma: powder
• Teszt: ≥95%

Tulajdonságok

• ligand: VH032
• Minőségi szint: 100
• Teszt: ≥95%
• Forma: powder
• reakcióalkalmasság: reactivity: amine reactive; reagent type: ligand-linker conjugate
• funkcionális csoport: carboxylic acid
• tárolási hőmérséklet: 2-8°C
• SMILES string: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NCCCCCCC(O)=O)=O.Cl
• InChI: 1S/C29H42N4O5S.ClH/c1-19-25(39-18-32-19)21-12-10-20(11-13-21)16-31-27(37)23-15-22(34)17-33(23)28(38)26(29(2,3)4)30-14-8-6-5-7-9-24(35)36;/h10-13,18,22-23,26,30,34H,5-9,14-17H2,1-4H3,(H,31,37)(H,35,36);1H/t22-,23+,26-;/m1./s1

Leírás

Alkalmazás

Protein degrader builiding block (S,R,S)-AHPC-C₆-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Egyéb megjegyzések

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Jogi információk

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable