G002

Isoguvacine hydrochloride

solid

• Synonyme(s) : 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
• Formule empirique (notation de Hill) : C₆H₉NO₂ · HCl
• Numéro CAS: 68547-97-7
• Poids moléculaire : 163.60
• NACRES: NA.77
• PubChem Substance ID: 24278160
• UNSPSC Code: 12352200
• MDL number: MFCD00055192
• Form: solid

Propriétés

• form: solid
• Quality Segment: 200
• color: white
• solubility: H₂O: soluble (refrigerate if not used immediately.), methanol: slightly soluble, neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily)
• SMILES string: Cl[H].OC(=O)C1=CCNCC1
• InChI: 1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
• InChI key: SUWREQRNTXCCBL-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Description

Application

Isoguvacine hydrochloride has been used as a γ-aminobutyric acid type A (GABA_A) receptor agonist:

• to study its effects on neuronal activity in rats[1]
• to study its antiallodynic effect in rats[2]
• to study its effects on baroreflex gains in rats

Biochem/physiol Actions

Isoguvacine is a strong γ-aminobutyric acid A (GABA_A) receptor agonist.[3]

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves