A0637
DL-2-Aminoadipic acid
≥99% (TLC), powder, gliotoxic
Synonyme(s) :
DL-α-Aminoadipic acid
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| Conditionnement | Référence | Disponibilité | Prix |
|---|---|---|---|
| 1 g | Vérifier la disponibilité des articles du panier | 90,60 € | |
| 5 g | Vérifier la disponibilité des articles du panier | 309,00 € | |
| 10 g | Vérifier la disponibilité des articles du panier | 531,00 € |
A propos de cet article
Formule linéaire :
HO2C(CH2)3CH(NH2)CO2H
Numéro CAS:
Poids moléculaire :
161.16
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
208-809-2
MDL number:
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DL-2-Aminoadipic acid, ≥99%
Quality Level
assay
≥99%
form
powder
mp
196-198 °C (lit.)
storage temp.
2-8°C
SMILES string
NC(CCCC(O)=O)C(O)=O
InChI
1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)
InChI key
OYIFNHCXNCRBQI-UHFFFAOYSA-N
Gene Information
rat ... Grin2b(24410)
Application
DL-2-Aminoadipic acid (AAA) has been used as an astrotoxin to kill astrocytes that prevent efficient integration of transplanted cells into the retina. It has also been used as a gliotoxin to study the effect of astrocytic swelling on the tortuosity.
Biochem/physiol Actions
DL-2-Aminoadipic acid (AAA) is a six-carbon homolog of glutamate and a gliotoxic compound. It is generally used to considerably reduce the number of astroglia in cerebellar cultures that acts as a model to study the mechanisms of a-aminoadipic acid induced glial toxicity.
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Cet article | |||
|---|---|---|---|
| assay ≥99% | assay 99% | assay ≥95% (TLC) | assay ≥98% |
| form powder | form solid | form powder | form powder |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
| Gene Information rat ... Grin2b(24410) | Gene Information - | Gene Information - | Gene Information - |
| mp 196-198 °C (lit.) | mp 260 °C (dec.) (lit.) | mp - | mp - |
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Contenu apparenté
Product Information Sheet
H Q Wu et al.
European journal of pharmacology, 281(1), 55-61 (1995-07-25)
L-alpha-Aminoadipic acid is a lysine metabolite with neuroexcitatory properties, and has previously been shown to inhibit the production of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid in brain tissue slices. The effects of L-alpha-aminoadipic acid on the
Huadong Ni et al.
Journal of neuroinflammation, 16(1), 1-1 (2019-01-05)
Despite accumulating evidence on the role of glial cells and their associated chemicals in mechanisms of pain, few studies have addressed the potential role of chemokines in the descending facilitation of chronic pain. We aimed to study the hypothesis that
Gliotoxic effects of $\alpha$-aminoadipic acid on monolayer cultures of dissociated postnatal mouse cerebellum
Huck S, et al.
Neuroscience, 12(3), 783-791 (1984)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| A0637-1G | 04061826687666 |
| A0637-10G | 04061833626931 |
| A0637-5G | 04061833626948 |