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E8280

Sigma-Aldrich

Exo 1

≥98% (HPLC), solid

Synonyme(s) :

2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate

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About This Item

Formule empirique (notation de Hill):
C15H12NFO3
Numéro CAS:
75541-83-2
Poids moléculaire :
273.26
Numéro MDL:
MFCD00028104
Code UNSPSC :
12352203
ID de substance PubChem :
24724477
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Solubilité

DMSO: soluble 19 mg/mL

Chaîne SMILES 

COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2

InChI

1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)

Clé InChI

KIAPWMKFHIKQOZ-UHFFFAOYSA-N

Application

Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long interspersed nuclear element-1 (L1) retrotransposition.

Actions biochimiques/physiologiques

Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.
Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Yan Feng et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(11), 6469-6474 (2003-05-10)
A phenotypic screen was used to search for drug-like molecules that can interfere with specific steps in membrane traffic. 2-(4-Fluorobenzoylamino)-benzoic acid methyl ester (Exo1), identified in this screen, induces a rapid collapse of the Golgi to the endoplasmic reticulum, thus
ALan F Rees et al.
Marine biology, 164(2), 30-30 (2017-01-31)
Many marine megavertebrate taxa, including sea turtles, disperse widely from their hatching or birthing locations but display natal homing as adults. We used flipper tagging, satellite tracking and genetics to identify the origin of loggerhead turtles living in Amvrakikos Gulf
Philip J Lester et al.
Scientific reports, 10(1), 12398-12398 (2020-07-28)
CRISPR gene drives have potential for widespread and cost-efficient pest control, but are highly controversial. We examined a potential gene drive targeting spermatogenesis to control the invasive common wasp (Vespula vulgaris) in New Zealand. Vespula wasps are haplodiploid. Their life
Time-lapse observation of chromosomes, cytoskeletons and cell organelles during male meiotic divisions in Drosophila
Tanabe K, et al.
Bio-protocol, 7, e2225-e2225 (2017)
Justin Chun et al.
Molecular biology of the cell, 19(8), 3488-3500 (2008-06-06)
Despite extensive work on ADP-ribosylation factor (Arf) 1 at the Golgi complex, the functions of Arf2-5 in the secretory pathway, or for that of any Arf at the ER-Golgi intermediate compartment (ERGIC) remain uncharacterized. Here, we examined the recruitment of
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