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E7280

Elafin

Name: Elafin
Brand: SIGMA
Price: 765 EUR

recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),

Synonyme(s) :

Elastase-specific inhibitor, skin-derived antileukoprotease

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Conditionnement	Référence	Disponibilité	Prix
100 μg		Vérifier la disponibilité des articles du panier	765,00 €

A propos de cet article

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00146824

765,00 €

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Propriétés

Nom du produit

Elafin human, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae

Quality Level

200

recombinant

expressed in Saccharomyces cerevisiae

assay

>90% (by MS, HPLC and SDS-PAGE)

form

powder

potency

1.7 x 10-10 M K_i (human leukocyte elastase), 4.2 x 10-10 M K_i (human proteinase 3)

mol wt

~6 kDa

UniProt accession no.

P19957

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

enzyme | inhibits

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... PI3(5266)

Description

General description

Chemical structure: peptide

Biochem/physiol Actions

Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.

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Cet article	94261	A6671	M7152
Sigma-Aldrich E7280 Elafin human	Sigma-Aldrich 94261 LL-37 (human) trifluoroacetate salt	Sigma-Aldrich A6671 Actinonin	Sigma-Aldrich M7152 Magainin I
assay >90% (by MS, HPLC and SDS-PAGE)	assay ≥95% (HPLC)	assay ≥98% (TLC)	assay ≥97% (HPLC)
Gene Information human ... PI3(5266)	Gene Information -	Gene Information human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)	Gene Information -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder (Lyophilisate)	form powder	form -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
shipped in ambient	shipped in -	shipped in -	shipped in -

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

0000560358

0000519386

0000269791

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Articles

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Contenu apparenté

Data Sheet - E7280

Datasheet

Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice.

Lingling Shu et al.

Clinical science (London, England : 1979), 134(13), 1679-1696 (2020-07-08)

Type 1 diabetes is an autoimmune disease resulted from self-destruction of insulin-producing pancreatic β cells. However, the pathological pathways that trigger the autoimmune destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with

Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis.

T Dau et al.

Scientific reports, 6, 35413-35413 (2016-10-16)

High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied

Human rElafin Inhibits HIV-1 Replication in Its Natural Target Cells.

Viraj J Jasinghe et al.

BioResearch open access, 2(2), 128-137 (2013-04-18)

Trappin-2/elafin is a novel innate immune factor that belongs to the serine protease inhibitor family and has known antibacterial, antifungal, and antiviral properties. In this study, we further investigated the anti-HIV activity of elafin using different cellular models and both

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Numéro d'article de commerce international

Référence	GTIN
E7280-100UG	04061833605035

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