D4007

5,5-Diphenylhydantoin

≥98%

• Synonyme(s) : 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin
• Formule empirique (notation de Hill) : C₁₅H₁₂N₂O₂
• Numéro CAS: 57-41-0
• Poids moléculaire : 252.27
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 24278370
• EC Number: 200-328-6
• Beilstein/REAXYS Number: 384532
• MDL number: MFCD00005264
• Assay: ≥98%
• Form: powder

Propriétés

• Quality Segment: 100
• assay: ≥98%
• form: powder
• mp: 293-295 °C (lit.)
• solubility: DMSO: soluble
• SMILES string: O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
• InChI key: CXOFVDLJLONNDW-UHFFFAOYSA-N
• Gene Information: human ... CNR1(1268), CNR2(1269), CYP2C9(1559), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) ; rat ... Faah(29347), Scn1a(81574), Scnn1g(24768), Slc6a1(79212)

Description

General description

5,5-Diphenylhydantoin is an anticonvulsant, which is used to treat tonic-clonic seizures, complex partial seizures and neurosurgical related seizures. It induces osteoblast proliferation and differentiation. 5,5-Diphenylhydantoin used to treat epilepsy. It reduces the hyperexcitability of tissues and may be associated with cerebellar atrophy.

Application

5,5-Diphenylhydantoin has been used for phenytoin treatment. It has also been used to slow down or prevent mesoendoderm cell migration.

Biochem/physiol Actions

Anticonvulsant.

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H351,H360FD
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges