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D3447

Doxycycline hydrochloride

Synonyme(s) :

2-Naphthacenecarboxamide, 4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aR,5S,5aR,6R,12aS)-

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ConditionnementRéférenceDisponibilitéPrix
500 mg
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75,90 €

A propos de cet article

Formule empirique (notation de Hill) :
C22H24N2O8 · HCl
Numéro CAS:
Poids moléculaire :
480.90
MDL number:
UNSPSC Code:
51284028
NACRES:
NA.85

75,90 €


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Quality Segment

biological source

synthetic

form

powder

color

yellow

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

mode of action

protein synthesis | interferes

storage temp.

−20°C

InChI

1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1

InChI key

VLUQVUWDECWBTL-UQVCFKGQSA-N

General description

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.

Application

Doxycycline hydrochloride has been used for the induction of shRNA expression and induction of expression vectors.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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1 of 1

Cet article
D3072D9891PHR1145
mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

-

antibiotic activity spectrum

Gram-negative bacteria, mycoplasma, Gram-positive bacteria, parasites

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

antibiotic activity spectrum

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

form

powder

form

liquid

form

powder

form

-

biological source

synthetic

biological source

synthetic

biological source

synthetic

biological source

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-10 to -25°C


pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Certificats d'analyse (COA)

Lot/Batch Number

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Numéro d'article de commerce international

RéférenceGTIN
D3447-500MG04061833563205

Questions

1–4 sur 4 questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. IS DOXYCYCLINE HYDROCHLORIDE (D3447) SOLUBLE IN WATER 50 MG/ML?

    1 réponse
    1. This product is soluble in water at 50 mg/ml.

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  4. What is the best way to solubilize the product for cell culture and animal use?

    1 réponse
    1. This product has not been tested for use in cell culture. However, product D5207 is a cell culture tested Doxycycline Hyclate. The Hyclate and the Hydrochloride salt forms are soluble in water at roughly equal rates. For dosing purposes, the unique molecular weight of each must be considered. Please see the link below to the product data sheet for the cell culture version of this product. This information offered in this document may be applied to the D3447:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/297/d5207dat.pdf

      Note that neither of these products are sterile. Prepared stock solutions must be filter sterilized prior to adding them to the culture medium.

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