D052

GBR 12909 dihydrochloride

≥98% (HPLC), dopamine transportef nhibitor, solid

• Synonyme(s) : 1-(2-[bis(4-Fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
• Formule empirique (notation de Hill) : C₂₈H₃₂F₂N₂O · 2HCl
• Numéro CAS: 67469-78-7
• Poids moléculaire : 523.49
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277909
• NACRES: NA.77
• MDL number: MFCD00055193
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Propriétés

• Nom du produit: GBR 12909 dihydrochloride, solid, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white
• solubility: DMSO: >5 mg/mL (Solutions freshly prepared daily)
• SMILES string: Cl.Cl.Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4
• InChI: 1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
• InChI key: MIBSKSYCRFWIRU-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Application

GBR 12909 dihydrochloride has been used as a dopamine transporter (DAT) inhibitor:

• to study its effects on LPS-induced mRNA expression on the proinflammatory cytokines in the mouse striatum
• to study its effects on neurotransmitter release in zebrafish brain[1]
• in DA uptake assay in mice striatal fraction[2]

Biochem/physiol Actions

GBR 12909 is a highly selective dopamine reuptake inhibitor with behavioral effects similar to cocaine.

GBR 12909 may show pharmacotherapeutic effects against cocaine addiction.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)