L1012

Linoleic acid

liquid, BioReagent, suitable for cell culture

• Szinonimák: cis-9,cis-12-Octadecadienoic acid
• Lineáris képlet: CH₃(CH₂)₄CH=CHCH₂CH=CH(CH₂)₇CO₂H
• CAS-szám: 60-33-3
• Molekulatömeg: 280.45
• Beilstein: 1727101
• EC-szám: 200-470-9
• MDL-szám: MFCD00064241
• UNSPSC kód: 12352211
• eCl@ss: 32190102
• PubChem Substance ID: 24896270
• NACRES: NA.75

Tulajdonságok

• biológiai forrás: plant (Safflower oil)
• Minőségi szint: 200
• termékcsalád: BioReagent
• Teszt: ≥98%
• form: liquid
• technika/technikák: cell culture | mammalian: suitable
• törésmutató: n20/D 1.466 (lit.)
• bp: 229-230 °C/16 mmHg (lit.)
• mp: −5 °C (lit.)
• oldhatóság: NaOH: 1 M; ethanol: soluble
• sűrűség: 0.902 g/mL at 25 °C (lit.)
• tárolási hőmérséklet: −20°C
• SMILES string: OC(CCCCCCC/C=C\C/C=C\CCCCC)=O
• InChI: 1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-
• Nemzetközi kémiai azonosító kulcs: OYHQOLUKZRVURQ-HZJYTTRNSA-N
• Géninformáció: human ... SOAT1(6646) , SOAT2(8435)

Leírás

Általános leírás

Linoleic acid (LA) is the precursor for the synthesis of arachidonic prostaglandins and other eicosanoids. LA is present in vegetable oils and meat.

Alkalmazás

Fatty acid that is typically bound to a carrier molecule such as BSA or cyclodextrin for use in cell culture.

Linoleic acid has been used as a component of S12 medium for cardiomyocytes differentiation, minimum essential medium α for spermatogonial stem cell culture and for endothelial differentiation of mouse adipose-derived stem cells (mASC).

Biokémiai/fiziológiai hatások

Linoleic acid (LA) may improve wound healing in diabetic rat. The levels of LA in adipose tissue and platelets are correlated with coronary artery disease. It may induce tumor and apoptosis in colorectal cancer cells. Studies also support their protective effects in lymphocytes. Linoleic acid is typically bound to a carrier molecule such as bovine serum albumin (BSA) or cyclodextrin for use in cell culture.

Linoleic acid increases cell proliferation and gene expression of PPARα and its target genes such as acyl-CoA oxidase in primary duck hepatocytes .

Kiszerelés

Sealed ampule.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)