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Merck

L8134

Sigma-Aldrich

Linoleic acid sodium salt

≥97% (GC)

Szinonimák:

Sodium linolate, Sodium linoleate, cis-9,cis-12-Octadecadienoic acid sodium salt

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

Lineáris képlet:
C18H31O2Na
CAS-szám:
Molekulatömeg:
302.43
EC-szám:
MDL-szám:
UNSPSC kód:
12352211
PubChem Substance ID:
NACRES:
NA.25

biológiai forrás

plant oil (safflower)

Minőségi szint

Teszt

≥97% (GC)

form

powder

technika/technikák

activity assay: suitable

szín

white

mp

230 °C (446 °F)

oldhatóság

methanol: 50 mg/mL, clear, yellow

alkalmazás(ok)

general analytical
life science and biopharma

funkcionális csoport

carboxylic acid

lipidtípus

omega FAs

kiszállítva

ambient

tárolási hőmérséklet

−20°C

SMILES string

[Na+].CCCCC\C=C/C\C=C/CCCCCCCC([O-])=O

InChI

1S/C18H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20);/q;+1/p-1/b7-6-,10-9-;

Nemzetközi kémiai azonosító kulcs

WYPBVHPKMJYUEO-NBTZWHCOSA-M

Általános leírás

Linoleic acid, an essential omega-6 polyunsaturated fatty acid (PUFA), serves as a precursor to arachidonic acid (AA), necessary for synthesizing prostaglandins and other eicosanoids. Being an essential fatty acid, linoleic acid must be acquired through diet as the body cannot produce it. Deficiencies in linoleic acid are linked to health issues such as impaired wound healing, growth retardation, and dermatitis. Arachidonate 15 Lipoxygenase (15-LO) metabolizes linoleic acid in both plants and animals, forming 9- and 13-hydroxyoctadecadienoic acid (HODE). This versatile molecule finds applications in biochemical, metabolomics, and lipidomics research, enabling investigations into various metabolic pathways and providing insights into lipid functions in living organisms.

Alkalmazás

Linoleic acid sodium salt has been used:
  • in the β-carotene-linoleic acid assay
  • as a component in basal medium to treat peripheral blood mononuclear cells (PBMCs)
  • in Dulbecco′s modified Eagle′s medium (DMEM)/F-12 HEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) to incubate human trophoblast-derived choriocarcinoma cells (BeWo) and study its effects on adherens junctions (AJ) marker level, cell layer permeability, and intracellular lipid accumulation

Biokémiai/fiziológiai hatások

Linoleic acid, as a component of acylglycosyl ceramides, plays a physiological role in maintaining the water permeability barrier of the skin. The deficiency of linoleic acid may cause poor growth or development, scaly dermatitis, and an impaired immune response in infants. It is used in cosmetic and personal care products. Linoleic acid is mainly used as emollients or moisturizers for skin, nails, and hair.

Tulajdonságok és előnyök

  • High-quality molecule suitable for mulitple research applications
  • Commonly employed in Metabolomics and Biochemical studies

Egyéb megjegyzések

For additional information on our range of Biochemicals, please complete this form.

Piktogramok

Exclamation mark

Figyelmeztetés

Warning

Figyelmeztető mondatok

Veszélyességi osztályok

Skin Irrit. 2

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

dust mask type N95 (US), Eyeshields, Gloves


Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

E P Kilsdonk et al.
Journal of lipid research, 33(9), 1373-1382 (1992-09-01)
Human endothelial cells (EA.hy 926 line) were loaded with cationized low density lipoprotein (LDL) and subsequently incubated with fatty acid/bovine serum albumin complexes. The fatty acids were palmitic, oleic, linoleic, arachidonic, and eicosapentaenoic acids. The preincubations resulted in extensively modified
Hila Seti et al.
Archives of physiology and biochemistry, 115(3), 127-136 (2009-06-02)
The insulin-like growth factor (IGF) system plays a critical role in normal growth and development as well as in malignant states. Most of the biological activities of the IGFs are mediated by the IGF-IR, which is over-expressed in most tumours
T Sakamoto et al.
Applied and environmental microbiology, 64(7), 2361-2366 (1998-07-02)
Laboratory conditions have been identified that cause the rapid death of cultures of cyanobacteria producing urease. Once the death phase had initiated in the stationary growth phase, cells were rapidly bleached of all pigmentation. Null mutations in the ureC gene
Moran Cohen-Berkman et al.
eLife, 9 (2020-03-28)
How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs
Miriam E van Gent et al.
Antibiotics (Basel, Switzerland), 11(5) (2022-05-29)
Recently, using a deep learning approach, the novel antibiotic halicin was discovered. We compared the antibacterial activities of two novel bactericidal antimicrobial agents, i.e., the synthetic antibacterial and antibiofilm peptide (SAAP)-148 with this antibiotic halicin. Results revealed that SAAP-148 was

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