1188800

Diclofenac sodium

United States Pharmacopeia (USP) Reference Standard

• Szinonimák: Diclofenac sodium salt, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
• Tapasztalati képlet (Hill-képlet): C₁₄H₁₀Cl₂NNaO₂
• CAS-szám: 15307-79-6
• Molekulatömeg: 318.13
• MDL-szám: MFCD00082251
• UNSPSC kód: 41116107
• PubChem Substance ID: 329749565
• NACRES: NA.24

Tulajdonságok

• grade: pharmaceutical primary standard
• API-család: diclofenac
• gyártó/kereskedő neve: USP
• alkalmazás(ok): pharmaceutical (small molecule)
• Formátum: neat
• SMILES string: [Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
• InChI: 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
• Nemzetközi kémiai azonosító kulcs: KPHWPUGNDIVLNH-UHFFFAOYSA-M
• Géninformáció: human ... PTGS1(5742) , PTGS2(5743)

Leírás

Általános leírás

Diclofenac sodium is a sodium salt of diclofenac, a non-steroidal anti-inflammatory drug (NSAID). It prevents the synthesis of prostaglandin involved in pain, inflammation, and fever by inhibiting the cyclooxygenase enzyme activity.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Diclofenac sodium USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare acid stage standard, standard, standard stock, sensitivity, and system suitability solution for the assay, impurity analysis, identification, and performance test by using liquid chromatography coupled with UV detector according to the given below monographs of United States Pharmacopeia (USP): 

• Diclofenac Sodium
• Diclofenac Sodium Delayed-Release Tablets  
• Diclofenac Sodium Extended-Release Tablets
• Diclofenac Sodium Topical Solution
• Diclofenac Sodium and Misoprostol Delayed-Release Tablets

Biokémiai/fiziológiai hatások

Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

Analízis megjegyzés

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Egyéb megjegyzések

Sales restrictions may apply.

Biztonsági adatok

• Piktogramok: GHS06,GHS08,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H301,H361d,H372,H411
• Óvintézkedésre vonatkozó mondatok: P202 - P260 - P264 - P270 - P273 - P301 + P310
• Veszélyességi osztályok: Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable