902578

Hydroxy-PEG6-t-butyl ester

≥95%

• Szinonimák: tert-Butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate, HO-PEG6-CO-OtBu
• Tapasztalati képlet (Hill-képlet): C₁₉H₃₈O₉
• CAS-szám: 361189-64-2
• Molekulatömeg: 410.50
• UNSPSC kód: 51171641
• NACRES: NA.22

Tulajdonságok

• Teszt: ≥95%
• form: liquid
• reakcióalkalmasság: reagent type: cross-linking reagent
• törésmutató: n/D 1.454
• sűrűség: 1.068
• funkcionális csoport: ester; hydroxyl
• tárolási hőmérséklet: −20°C
• SMILES string: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCO
• InChI: 1S/C19H38O9/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h20H,4-17H2,1-3H3
• Nemzetközi kémiai azonosító kulcs: VGGDPFAYSOSIOK-UHFFFAOYSA-N

Leírás

Alkalmazás

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Egyéb megjegyzések

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Jogi információk

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable