902691

Hydroxy-PEG5-t-butyl ester

• Szinonimák: tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
• Tapasztalati képlet (Hill-képlet): C₁₇H₃₄O₈
• CAS-szám: 850090-09-4
• Molekulatömeg: 366.45
• MDL-szám: MFCD20926402
• UNSPSC kód: 51171641
• Forma: liquid
• Teszt: ≥95%

Tulajdonságok

• Teszt: ≥95%
• Forma: liquid
• reakcióalkalmasság: reagent type: cross-linking reagent
• törésmutató: n/D 1.448
• sűrűség: 1.071
• funkcionális csoport: ester; hydroxyl
• tárolási hőmérséklet: −20°C
• SMILES string: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

Leírás

Alkalmazás

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Egyéb megjegyzések

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

Jogi információk

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable