T8578

Anti-β-Tubulin III Antibody

mouse monoclonal, 2G10

• Szinonimák: Anti-β-Tubulin Class III, Anti-Neuron-specifc class III β-tubulin, Anti-TUBB4, Anti-Tubb3, Anti-Tubulin β-4, Anti-Tubulin β-III, Anti-Tubulin, β−3
• MDL-szám: MFCD01323870
• UNSPSC kód: 12352203
• NACRES: NA.41

Tulajdonságok

• product name: Anti-β-Tubulin III (neuronal) antibody, Mouse monoclonal, ~1.0 mg/mL, clone 2G10, purified from hybridoma cell culture
• biológiai forrás: mouse
• Minőségi szint: 200
• konjugátum: unconjugated
• antitest forma: purified from hybridoma cell culture
• antitest terméktípus: primary antibodies
• klón: 2G10, monoclonal
• form: buffered aqueous solution
• molekulatömeg: antigen ~50 kDa
• faj reaktivitás: human, mouse, rat
• kiszerelés: antibody small pack of 25 μL
• koncentráció: ~1.0 mg/mL
• technika/technikák: immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: 0.25-0.5 μg/mL using PC12 cell extract
• izotípus: IgG2a
• UniProt elérési szám: Q13509
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... TUBB3(10381) ; mouse ... Tubb3(22152) ; rat ... Tubb3(246118)

Leírás

Általános leírás

Tubulin β 3 class III (TUBB3) also known as β-Tubulin III, is encoded by the gene mapped to human chromosome 16q24.3. TUBB3 protein expression is restricted to neurons.

Alkalmazás

Monoclonal Anti-β-Tubulin III (neuronal) antibody produced in mouse has been used in following studies:

• Immunofluorescence.
• Immunocytochemistry.

Biokémiai/fiziológiai hatások

Tubulin β 3 class III (TUBB3) plays a vital role in nervous system development and axon guidance. Mutation of the gene encoding protein leads to the ocular motility disorder, congenital fibrosis of the extraocular muscle type 3 (CFEOM3), and various neurological syndromes. Altered expression of the protein affects microtubule dynamics and microtubule-kinesin interactions. Increased expression of TUBB3 is observed in tumor tissues. Decreased expression of TUBB3 can be considered as an important marker for poor prognosis of cutaneous malignant melanoma. TUBB3 is implicated in the suppression of invasive growth of tumor tissue;therefore, it is considered to be a potential target for development of antitumor drugs.

Fizikai forma

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Egyéb megjegyzések

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)