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Merck
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Fontos dokumentumok

ABE457

Sigma-Aldrich

Anti-c-Fos Antibody

rabbit polyclonal

Szinonimák:

Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
klón:
polyclonal
application:
IHC
WB
faj reaktivitás:
human, rat
technika/technikák:
immunohistochemistry: suitable (paraffin)
western blot: suitable
citations:
225

Terméknév

Anti-c-Fos Antibody, from rabbit, purified by affinity chromatography

biológiai forrás

rabbit

Minőségi szint

100

antitest forma

affinity isolated antibody

antitest terméktípus

primary antibodies

klón

polyclonal

tisztítva

affinity chromatography

faj reaktivitás

human, rat

faj reaktivitás (homológia által előrejelzett)

sheep (based on 100% sequence homology), mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), porcine (based on 100% sequence homology)

technika/technikák

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI elérési szám

NP_005243

UniProt elérési szám

P01100

kiszállítva

wet ice

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... FOS(2353)

Általános leírás

c-Fos is a member of a family of immediate early gene (IEG) transcription factors (other members include Jun and Egr-1) also identified as proto-oncogenes. The basal expression of c-Fos and other IEGs is typically low but increases relatively quickly and often dramatically (15-30 min for mRNA; 30-60 min for protein) in response to changes in cellular activity typically caused by external stimuli, such as stress or neuronal activation. Thus, these IEGs are being used to indicate specific activity driven cellular activation including the identification of neurons activated by various growth factors, neuroactive drugs, and correlated changes in behavioral or physiological states.

Egyediség

This antibody recognizes the N-terminus of c-Fos.

Immunogén

KLH-conjugated linear peptide corresponding to the N-terminus of human c-Fos.

Alkalmazás

Anti-c-Fos Antibody is a Rabbit Polyclonal Antibody for detection of c-Fos also known as Proto-oncogene c-Fos, Cellular oncogene fos & has been validated in WB & IHC.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected c-Fos in rat pons and rat cerebellum tissues.

Immunofluorescence Analysis: A representative lot detected c-Fos in rat pons and rat cerebellum tissues.

Minőség

Evaluated by Western Blot in PMA(TPA) treated HeLa cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected c-Fos in 10 µg of PMA(TPA) treated HeLa cell lysate.

Cél megnevezése

~60/56 kDa observed. This protein has multiple isoforms produced by alternative splicing ranging between 53 and 68 kDa (Jurado, J., et al. (2007). BMC Molecular Biology. 8:83-96.)

Analízis megjegyzés

Control
PMA(TPA) treated HeLa cell lysate

Egyéb megjegyzések

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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összehasonlítható termékek

Product No.
Leírás
Árazás

Tárolási osztály kódja

12 - Non Combustible Liquids

WGK

WGK 1

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Isabel F Augur et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(39), 10174-10180 (2016-09-30)
The ventromedial prefrontal cortex (vmPFC) has been shown to negatively regulate cocaine-seeking behavior, but the precise conditions by which vmPFC activity can be exploited to reduce cocaine relapse are currently unknown. We used viral-mediated gene transfer of designer receptors (DREADDs)
Sydney Aten et al.
Neuropharmacology, 144, 256-270 (2018-10-21)
miR-132 and miR-212 are structurally-related microRNAs that are expressed from the same non-coding transcript. Accumulating evidence has shown that the dysregulation of these microRNAs contributes to aberrant neuronal plasticity and gene expression in the mammalian brain. Consistent with this, altered
Min-Yu Sun et al.
Scientific reports, 9(1), 16431-16431 (2019-11-13)
Pentameric GABAA receptors mediate a large share of CNS inhibition. The γ2 subunit is a typical constituent. At least 11 mutations in the γ2 subunit cause human epilepsies, making the role of γ2-containing receptors in brain function of keen basic
Anett J Nagy et al.
PLoS biology, 16(6), e2004712-e2004712 (2018-06-26)
Evolutionary development of vision has provided us with the capacity to detect moving objects. Concordant shifts of visual features suggest movements of the observer, whereas discordant changes are more likely to be indicating independently moving objects, such as predators or
Ozra Dehkordi et al.
Journal of alcoholism and drug dependence, 5(4) (2017-10-19)
Orexin/hypocretin-containing neurons in lateral hypothalamus (LH) are implicated in the neurobiology of nicotine addiction. However, the neuroanatomical relationships between orexin-neurons/nerve fibers and nicotine-activated cells within the reward-addiction neurocircuitry is not known. In the present study in mice, we first used
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