SML0580

Nutlin-3a

≥98% (HPLC)

• Szinonimák: (-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one, (-)-Nutlin-3, 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one, 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone, Nutlin 3a
• Tapasztalati képlet (Hill-képlet): C₃₀H₃₀Cl₂N₄O₄
• CAS-szám: 675576-98-4
• Molekulatömeg: 581.49
• MDL-szám: MFCD14636430
• UNSPSC kód: 12352200
• PubChem Substance ID: 329825564
• NACRES: NA.77

Tulajdonságok

• ligand: nutlin-3a
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• form: powder
• optikai aktivitás: [α]/D -130 to -154° (c=0.5, CDCl3)
• reakcióalkalmasság: reagent type: ligand
• szín: white to beige
• oldhatóság: DMSO: 5 mg/mL, clear
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• SMILES string: O=C(N1CC(NCC1)=O)N2[C@H](C3=CC=C(Cl)C=C3)[C@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C
• InChI: 1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
• Nemzetközi kémiai azonosító kulcs: BDUHCSBCVGXTJM-WUFINQPMSA-N

Leírás

Alkalmazás

Nutlin-3a has been used as a tumor suppressor p53(TP53) stabilizer and as an inhibitor of the mouse double minute 2 homolog (MDM2)–p53 interaction.

Biokémiai/fiziológiai hatások

Nutlin-3a [(-)-Nutlin] is a more potent diastereoisomer of racemic MDM2 antagonist Nutlin-3. It was called enantiomer-a since it elutes as the first peak from chiral purification of racemic nutlin-3. Nutlin-3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. Nutlin-3a is 150 times more potent than Nutlin-3b.

Nutlin-3a is a potent nongenotoxic drug. It acts as a tumor suppressor p53 (TP53) activator and stabilizer.

Tulajdonságok és előnyök

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable