PHR1014

Hydrocortisone

Pharmaceutical Secondary Standard; Certified Reference Material

• Szinonimák: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
• Tapasztalati képlet (Hill-képlet): C₂₁H₃₀O₅
• CAS-szám: 50-23-7
• Molekulatömeg: 362.46
• Beilstein: 1354819
• EC-szám: 200-020-1
• MDL-szám: MFCD00011654
• UNSPSC kód: 41116107
• PubChem Substance ID: 329823045
• NACRES: NA.24

Tulajdonságok

• grade: certified reference material; pharmaceutical secondary standard
• Minőségi szint: 300
• Ügynökség: traceable to BP 576; traceable to Ph. Eur. H1300000; traceable to USP 1316004
• API-család: hydrocortisone
• Analitikai műbizonylat: current certificate can be downloaded
• technika/technikák: HPLC: suitable; gas chromatography (GC): suitable
• mp: 211-214 °C (lit.)
• alkalmazás(ok): pharmaceutical (small molecule)
• Formátum: neat
• tárolási hőmérséklet: 2-30°C
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• Nemzetközi kémiai azonosító kulcs: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Géninformáció: human ... NR3C1(2908)

Leírás

Általános leírás

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydrocortisone is a degradation product of the corticosteroid, hydrocortisone acetate.

Alkalmazás

Hydrocortisone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biokémiai/fiziológiai hatások

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

Analízis megjegyzés

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Egyéb megjegyzések

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Lábjegyzet

To see an example of a Certificate of Analysis for this material enter LRAB3713 in the slot below. This is an example certificate only and may not be the lot that you receive.

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H360Df,H373
• Óvintézkedésre vonatkozó mondatok: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Veszélyességi osztályok: Repr. 1A - STOT RE 2
• Célzott szervek: Adrenal gland,Bone marrow
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable