H0888

Hydrocortisone

BioReagent, suitable for cell culture

• Szinonimák: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
• Tapasztalati képlet (Hill-képlet): C₂₁H₃₀O₅
• CAS-szám: 50-23-7
• Molekulatömeg: 362.46
• Beilstein: 1354819
• EC-szám: 200-020-1
• MDL-szám: MFCD00011654
• UNSPSC kód: 12352209
• PubChem Substance ID: 24895415
• NACRES: NA.77

Tulajdonságok

• termékcsalád: BioReagent
• Minőségi szint: 200
• Teszt: ≥98%
• form: powder
• technika/technikák: cell culture | mammalian: suitable
• mp: 211-214 °C (lit.)
• oldhatóság: chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow
• kiszállítva: ambient
• tárolási hőmérséklet: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• Nemzetközi kémiai azonosító kulcs: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Géninformáció: human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866) ; mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) ; rat ... Ar(24208) , Nr3c1(24413)

Leírás

Alkalmazás

Hydrocortisone has been used as a supplement in culture media for oligodendrocytes, colon cells and epithelial cells.

Biokémiai/fiziológiai hatások

Hydrocortisone (also referred to as cortisol) is an endogenous glucocorticoid which is secreted by the adrenal gland. It is produced from the hypothalamus–pituitary–adrenal (HPA) axis. Hydrocortisone interacts with glucocorticoid receptors and regulates various signaling pathways. It is associated with the induction of energy mobilization, increase in cerebral perfusion rates and local glucose consumption. It is also linked with increase in cardiovascular output and respiration, redistribution of blood, delivery of molecules and energy to the brain and muscles and modulation of immune responses.

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Fizikai forma

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Feloldás

To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H360Df,H373
• Óvintézkedésre vonatkozó mondatok: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Veszélyességi osztályok: Repr. 1A - STOT RE 2
• Célzott szervek: Adrenal gland,Bone marrow
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges