Skip to Content
Merck

Key Documents

View All Documentation

Skip To

L2898

Lysostaphin from Staphylococcus staphylolyticus

aseptically filled

Synonym(s):

Glycyl-glycine Endopeptidase

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
1 mg

Estimated to ship on22 de abril de 2026fromCajamar

R$ 3.153,00

About This Item

CAS Number:
9011-93-2
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
3.4.24.75 (BRENDA, IUBMB)
MDL number:
MFCD00131556
Specific activity:
>500 units/mg protein

R$ 3.153,00

Estimated to ship on22 de abril de 2026Details

To order products, please contact your local dealer.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

sterility

aseptically filled

Quality Level

200

form

powder

specific activity

>500 units/mg protein

mol wt

25 kDa

composition

Protein, 40-70% biuret

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

−20°C

General description

Lysostaphin is mainly liberated as a proenzyme. It is highly stable at pH 4 and temperature 5°C.
Chemical structure: peptide

Biochem/physiol Actions

Lysostaphin exhibit a lytic action against Staphylococcus aureus. It possesses several functions of three major enzymes, such as, glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acteyl muramyl-L-alanine amidase. Lysostaphin can be used to treat antibiotic-resistant staphylococcal infections. Lysostaphin being an antistaphylococcal agent, can be used as a preservative in the food industry and in clinical labs for rapid screening.
Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic.
pH Optimum for activity: ~7.5

Preparation Note

Prepared from L 7386

Other Notes

One unit will reduce the turbidity (A620) of a suspension of Staphylococcus aureus cells from 0.250 to 0.125 in 10 min at pH 7.5 at 37 °C in a 6.0 ml reaction mixture.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SRE0053L7386SAE0091
Lysostaphin from Staphylococcus staphylolyticus aseptically filled

Sigma-Aldrich

L2898

Lysostaphin from Staphylococcus staphylolyticus

Lysostaphin from Staphylococcus staphylolyticus Suitable for manufacturing of diagnostic kits and reagents., lyophilized powder

Sigma-Aldrich

SRE0053

Lysostaphin from Staphylococcus staphylolyticus

Lysostaphin from Staphylococcus staphylolyticus lyophilized powder, Protein 50-70 % by biuret, ≥500 units/mg protein

Sigma-Aldrich

L7386

Lysostaphin from Staphylococcus staphylolyticus

Lysostaphin from Staphylococcus staphylolyticus free of DNA contaminants, suitable for Microbiome research, lyophilized powder, ≥500 units/mg protein

Sigma-Aldrich

SAE0091

Lysostaphin from Staphylococcus staphylolyticus

specific activity

>500 units/mg protein

specific activity

≥500 units/mg protein

specific activity

≥500 units/mg protein

specific activity

≥500 units/mg protein

form

powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

sterility

aseptically filled

sterility

-

sterility

-

sterility

-

mol wt

25 kDa

mol wt

26,926 Da

mol wt

25 kDa

mol wt

27 kDa

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

-

Still not finding the right product?

Explore all of our products under Lysostaphin from Staphylococcus staphylolyticus

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000493980
0000493980
SLCR3968
SLCR3968
SLCG3890

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Lysostaphin: an antistaphylococcal agent
Kumar J K
Applied Microbiology and Biotechnology, 80(4), 555-561 (2008)
R Satishkumar et al.
Nanotechnology, 22(50), 505103-505103 (2011-11-24)
The objective of this paper was to study the effect of antibody-directed targeting of S. aureus by comparing the activities of lysostaphin conjugated to biodegradable polylactide nanoparticles (NPs) in the presence and in the absence of co-immobilized anti-S. aureus antibody.
Thomas S Lawson et al.
Journal of clinical laboratory analysis, 25(5), 359-365 (2011-09-16)
Aspects of the fluorescence in situ hybridization (FISH) method for the detection of clinically important bacteria, such as Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli, were investigated for optimization. Various approaches to optimizing the FISH procedure were taken and different
View All Related Papers

Global Trade Item Number

SKUGTIN
L2898-1MG04061835557523

Questions

  1. Which reaction buffer is recommended for this enzyme? Are there any limitations, inhibitors, etc? Would it work in any medium.

    1 answer

    1. Please see the link below to the quality control test procedure utilized for the enzymatic assay of lysostaphin. Reaction with other buffers has not been tested and, please refer to academic literature for guidance on how other buffers may influence the enzyme's reactivity:

      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/120/423/l7386enz.pdf

      Helpful?

Reviews

No rating value

Active Filters