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14-306-M

Białko GSK3β, aktywne, 10 µg

Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 μg

Przewidywany termin wysyłki19 maja 2026zKuehne + Nagel Sp. z o.o.

2320,00 zł
250 μg

Przewidywany termin wysyłki29 maja 2026zKuehne + Nagel Sp. z o.o.

16 030,00 zł

Informacje o tej pozycji

UNSPSC Code:
12352202
NACRES:
NA.26
eCl@ss:
32160405
Form:
liquid
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
Mol wt:
Mw 51 kDa

2320,00 zł

Przewidywany termin wysyłki19 maja 2026Szczegóły

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biological source

human

Quality Level

100

recombinant

expressed in baculovirus infected Sf21 cells

form

liquid

mol wt

Mw 51 kDa

composition

mercaptoethanol, 0.1-1% , saccharose, 5-10%

manufacturer/tradename

Upstate®

storage condition

(Tightly closed)

technique(s)

activity assay: suitable (kinase)

solubility

water: soluble

NCBI accession no.

NM_002093.2

UniProt accession no.

P49841

Gene Information

human ... GSK3B(2932)

General description

Glycogen synthase kinase 3β (GSK3β) is a serine-threonine kinase that is present in most eukaryotes. The GSK3β gene is located on the human chromosome at 3q13.3.[1] GSK3β is made up of an N-terminal β-sheet domain that is coupled to the C-terminal α-helical domain.

Research area: Cell Signaling

Biochem/physiol Actions

Glycogen synthase kinase 3β (GSK3β) regulates glycogen metabolism[2] via an insulin-dependent pathway.[1] It participates in many signaling pathways including cellular processes such as cell cycle, cell proliferation, and inflammation. GSK3β mediated-negative regulation of insulin signaling pathway leads to type 2 diabetes.[2] GSK3β functions as a tumor suppressor that represses neoplastic transformation in cells. It is an essential regulator of the Wnt/β-catenin signaling pathway. Abnormal regulation of GSK3β is associated with cardiovascular disease, bipolar disorder, and neurodegenerative diseases.[1]

Packaging

Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-306M when ordering the 250μg size.

Analysis Note

Routinely evaluated by phosphorylation of Phospho-Glycogen Synthase Peptide-2

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Ta pozycja
SRP035614-429-M14-918-M
GSK3β Protein, active, 10 µg Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.

Sigma-Aldrich

14-306-M

GSK3β Protein, active, 10 µg

GSK3β active human recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Sigma-Aldrich

SRP0356

GSK3β active human

MEK1 Protein, active, 10 µg Active, N-terminal GST & C-terminal His6-tagged, recombinant full-length human MEK1, for use in Kinase Assays.

Sigma-Aldrich

14-429-M

MEK1 Protein, active, 10 µg

JAK1 Protein, active, 10 µg Active, N-terminal GST-tagged, recombinant, human JAK1, amino acids 866-end, expressed by baculovirus in Sf21 insect cells. Activated in vitro by auto-phosphorylation. For use in Kinase Assays.

Sigma-Aldrich

14-918-M

JAK1 Protein, active, 10 µg

biological source

human

biological source

human

biological source

human

biological source

human

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable, inhibition assay: suitable

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

Mw 51 kDa

mol wt

73 kDa

mol wt

Mw 71 kDa

mol wt

Mw 61 kDa

form

liquid

form

aqueous solution

form

liquid

form

-

UniProt accession no.

P49841

UniProt accession no.

P49841

UniProt accession no.

Q02750

UniProt accession no.

P23458

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Klasa składowania

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

rystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
Dajani R, et al.
Cell, 105(6), 721-732 (2009)
S Phukan et al.
British journal of pharmacology, 160(1), 1-19 (2010-03-25)
Glycogen synthase kinase-3 beta (GSK3beta) is a multifunctional serine/threonine kinase which was originally identified as a regulator of glycogen metabolism. It plays a key role in the regulation of numerous signalling pathways including cellular process such as cell cycle, inflammation
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro.
Sutherland, C and Cohen, P
Febs Letters, 338, 37-42 (1994)
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Numer pozycji handlu globalnego

SKUNUMER GTIN
14-30604053252409486
14-306M04053252370427

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