SRP3017
BMP-6 human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
Szinonimák:
VGR
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352202
NACRES:
NA.32
Javasolt termékek
biológiai forrás
human
rekombináns
expressed in HEK 293 cells
Teszt
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
hatékonyság
0.03-0.06 μg/mL ED50
molekulatömeg
26.2 kDa
kiszerelés
pkg of 10 μg
technika/technikák
cell culture | mammalian: suitable
szennyeződések
<0.1 EU/μg endotoxin, tested
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... BMP6(654)
Általános leírás
BMP6 (bone morphogenetic protein 6) is one of the BMPs which are secreted signaling proteins belonging to the transforming growth factor-β (TGF-β) superfamily. This gene is localized to human chromosome 6p24.1.
Recombinant human BMP-6 is a 26.2kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Recombinant human BMP-6 is a 26.2kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Biokémiai/fiziológiai hatások
BMPs (bone morphogenetic proteins) were initially identified from demineralized bone extracts capable of stimulating endochondral osteogenesis at extraskeletal sites in vivo. BMP6 is thought to be involved in early embryogenesis. In hepatocellular carcinoma (HCC) the expression of this protein is suppressed due to hypermethylation, and this is linked with poor patient outcomes. This protein is also down-regulated due to CpG island methylation in CRC (colorectal carcinoma), although it is not yet been found to be linked with tumor progression or prognosis. BMP6 is involved in chondrocyte differentiation, and in fetal kidney and urinary system development. It is thought to be involved in ovulation, where it elevates the accumulation of neutrophils in ovulatory follicles and reduces the influence of protease inhibitors.
Szekvencia
VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
Fizikai forma
Lyophilized from 10 mM Tris, pH 9.0.
Feloldás
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az ügyfelek ezeket is megtekintették
Expression of BMP6 is associated with its methylation status in colorectal cancer tissue but lacks prognostic significance.
Sangplod P et al
Asian Pacific Journal of Cancer Prevention, 15(17), 7091-7095 (2014)
Hypermethylation leads to bone morphogenetic protein 6 downregulation in hepatocellular carcinoma.
He Y et al
PLoS ONE, 9(1), e87994-e87994 (2014)
Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia.
Sebastiani P et al
Nature Genetics, 37(4), 435-440 (2005)
The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary.
Akiyama I et al
Reproductive Sciences, 21(6), 772-777 (2014)
S M Lens et al.
Seminars in immunology, 10(6), 491-499 (1998-11-25)
In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors, whereas for the
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