O4000

Oxythiamine chloride hydrochloride

≥95% (HPLC)

• Szinonimák: 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
• Tapasztalati képlet (Hill-képlet): C₁₂H₁₆ClN₃O₂S · HCl
• CAS-szám: 614-05-1
• Molekulatömeg: 338.25
• MDL-szám: MFCD00050656
• UNSPSC kód: 12352116
• PubChem Substance ID: 24897990
• NACRES: NA.79

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥95% (HPLC)
• Forma: powder
• technika/technikák: HPLC: suitable
• szín: white to off-white
• tárolási hőmérséklet: −20°C
• SMILES string: CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-]
• InChI: 1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H
• Nemzetközi kémiai azonosító kulcs: QHUYPZVMEJLSEB-UHFFFAOYSA-N

Leírás

Általános leírás

Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.

Alkalmazás

Oxythiamine chloride hydrochloride is suitable for use:

• as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
• as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
• in the synthesis of oxythiamineH picrolonate salt

Biokémiai/fiziológiai hatások

Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.

Oxythiamine inhibits Transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)