Összes fotó(5)
Fontos dokumentumok
D8375
2-Deoxy-D-glucose
≥98% (GC), crystalline
Szinonimák:
2-Deoxyglucose, 2-Deoxy-D-arabinohexose
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(5)
About This Item
Tapasztalati képlet (Hill-képlet):
C6H12O5
CAS-szám:
Molekulatömeg:
164.16
Beilstein:
1723331
EC-szám:
MDL-szám:
UNSPSC kód:
12352201
PubChem Substance ID:
NACRES:
NA.25
Javasolt termékek
biológiai forrás
synthetic
Minőségi szint
Teszt
≥98% (GC)
Forma
crystalline
technika/technikák
gas chromatography (GC): suitable
inhibition assay: suitable
szín
white to off-white
mp
146-147 °C (lit.)
oldhatóság
H2O: 0.250 g/5mL
alkalmazás(ok)
clinical research
life science and biopharma
metabolomics
tárolási hőmérséklet
2-8°C
SMILES string
OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
InChI
1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
Nemzetközi kémiai azonosító kulcs
VRYALKFFQXWPIH-PBXRRBTRSA-N
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Általános leírás
2-Deoxy-D-glucose, a non-metabolizable glucose analogue, disrupts glycolysis by targeting hexokinase, the rate-limiting step in glycolysis. Phosphorylated to 2-DG-P by hexokinase, it accumulates in the cell, depleting cellular ATP. This approach, effective in starving and killing cancer cells, may also inhibit virus cells reliant on glycolysis for replication. This versatile molecule finds application in cancer, virology, metabolomics and biochemical research.
Alkalmazás
2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biokémiai/fiziológiai hatások
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.
Tulajdonságok és előnyök
- High-purity compound suitable for a wide variety of research applications
Kiszerelés
Bottomless glass bottle. Contents are inside inserted fused cone.
Egyéb megjegyzések
For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
összehasonlítható termékek
Product No.
Leírás
Árazás
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
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Cikkek
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
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