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L6143

Sigma-Aldrich

Lipopolysaccharides from Salmonella enterica serotype typhimurium

suitable for cell culture, BioXtra, γ-irradiated

Szinonimák:

LPS

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

MDL-szám:
MFCD00164404
UNSPSC kód:
12352201
NACRES:
NA.75

biológiai forrás

Salmonella enterica (serotype typhimurium)

Minőségi szint

200

sterilitás

γ-irradiated

termékcsalád

BioXtra

form

lyophilized powder

tisztítva

gel-filtration chromatography

technika/technikák

cell culture | mammalian: suitable

szennyeződések

<1% Protein (Lowry)

tárolási hőmérséklet

2-8°C

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Alkalmazás

Lipopolysaccharides from Salmonella enterica serotype typhimurium has been used:
  • in mice to elicit the secretion of pro-inflammatory cytokines
  • to induce cytokine production in monocytes
  • to elicit the activation of NF-κB pathway in mouse dendritic cells.
  • to induce inflammatory response in human colon adenocarcinoma Caco-2 cells
  • for stimulation of the catfish peripheral blood leukocytes (PBLs) to study estrogen receptor mRNA expression
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Biokémiai/fiziológiai hatások

LPS is a major constituent of the cell wall of most gram negative bacteria. It is a highly immunogenic antigen with the ability to enhance immune responses to soluble antigens. LPS also acts as a specific mitogen for bone marrow derived B lymphocytes from mice, rabbits, chickens, cows, hamsters, and humans.

Feloldás

Lipopolysaccharides are supplied as lyophilized, γ-irradiated powders. To reconstitute, add 1 ml sterile balanced salt solution or tissue culture medium to the vial (1 mg) and gently swirl until the powder dissolves. Reconstituted product may be further diluted to desired working concentrations using sterile balanced salt solution or tissue culture medium.

Egyéb megjegyzések

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

kapcsolódó termék

Product No.
Leírás
Árazás

L6016

Lipopolysaccharides (rough strains) from Salmonella enterica serotype typhimurium TV119 (Ra mutant)

L7261

Lipopolysaccharides from Salmonella enterica serotype typhimurium, purified by trichloroacetic acid extraction

L6143

Lipopolysaccharides from Salmonella enterica serotype typhimurium, suitable for cell culture, BioXtra, γ-irradiated

L2262

Lipopolysaccharides from Salmonella enterica serotype typhimurium, purified by gel-filtration chromatography

L6511

Lipopolysaccharides from Salmonella enterica serotype typhimurium, purified by phenol extraction

L9516

Lipopolysaccharides (rough strains) from Salmonella enterica serotype typhimurium SL1181

Piktogramok

Exclamation mark
GHS07

Figyelmeztetés

Warning

Figyelmeztető mondatok

H302 + H312 + H332

Veszélyességi osztályok

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Luke R Iwanowicz et al.
Fish & shellfish immunology, 40(1), 109-119 (2014-06-29)
Estrogens are recognized as modulators of immune responses in mammals and teleosts. While it is known that the effects of estrogens are mediated via leukocyte-specific estrogen receptors (ERs) in humans and mice, leucocyte-specific estrogen receptor expression and the effects of
Guangwei Xu et al.
Journal of enzyme inhibition and medicinal chemistry, 33(1), 1089-1094 (2018-06-23)
Indoleamine 2,3-dioxygenase 1 (IDO1) activity links to immune escape of cancers. Inhibition of IDO1 provides a new approach for cancer treatment. Most clinical IDO1 drugs show marginal efficacy as single agents. On basis of molecular docking and pharmacophore modelling, a
Anna R Tröscher et al.
Acta neuropathologica, 137(4), 619-635 (2019-01-22)
Microglia nodule formation is a common feature in inflammatory brain diseases mediated by T lymphocytes such as viral and paraneoplastic encephalitis, multiple sclerosis, and Rasmussen encephalitis (RE). However, its role has not been fully understood yet. We hypothesized that, in
Stefania De Santis et al.
Oncotarget, 7(46), 75800-75809 (2016-10-08)
Dendritic cells (DCs) are professional antigen presenting cells (APCs) that in response to microbial infections generate long-lasting adaptive immune response. Following microbial uptake, DCs undergo a cascade of cellular differentiation that ultimately leads to "mature" DCs. Mature DCs produce a
Mike Tsz Hin Ng et al.
Infection and immunity, 78(3), 1345-1352 (2009-12-30)
Colonization of the gastric mucosa by Helicobacter pylori can lead to serious clinical outcomes, including gastric cancer. Toll-like receptors (TLRs) play an important role in the host response to H. pylori through the recognition of pathogen-associated molecular patterns. TLR9, in
View All Related Papers

Cikkek

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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