437650

Lipopolysaccharide

from Salmonella typhimurium, , lyophilized, iNOS stimulator, Calbiochem

• Szinonimák: Salmonella LPS, Salmonella endotoxin
• UNSPSC kód: 12352201
• NACRES: NA.77

Tulajdonságok

• Terméknév: Lipopolysaccharide, Salmonella typhimurium, Stimulates the activity of inducible nitric oxide synthase.
• Minőségi szint: 100
• Forma: lyophilized
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze
• szennyeződések: ≤2% nucleic acid; ≤2% protein
• oldhatóság: water: 5 mg/mL
• kiszállítva: ambient
• tárolási hőmérséklet: 2-8°C

Leírás

Általános leírás

Endotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define revelent pathophysiological parameters of endotoxin shock, a profound life-threatening consequence of bacterial sepsis. More recently, these bacterial products have generated intense interest due to their pluripotential immunostimulatory activity, as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cells activated by lipopolysaccharides produce a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

Biokémiai/fiziológiai hatások

Cell permeable: no

Primary Target
Inducible nitric oxide synthase

Product does not compete with ATP.

Reversible: no

Figyelmeztetés

Toxicity: Harmful (C)

Feloldás

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.

Egyéb megjegyzések

Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun.63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun.61, 5044.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Piktogramok: GHS06
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H300
• Óvintézkedésre vonatkozó mondatok: P264 - P270 - P301 + P310 - P405 - P501
• Veszélyességi osztályok: Acute Tox. 2 Oral
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable