J4580

Jasplakinolide

≥97% (HPLC), film (colorless), actin polymerization promoter

• Szinonimák: Jaspamide
• Tapasztalati képlet (Hill-képlet): C₃₆H₄₅BrN₄O₆
• CAS-szám: 102396-24-7
• Molekulatömeg: 709.67
• MDL-szám: MFCD00873735
• UNSPSC kód: 12352200
• PubChem Substance ID: 329815735
• NACRES: NA.77

Tulajdonságok

• Terméknév: Jasplakinolide, ≥97% (HPLC)
• Minőségi szint: 100
• Teszt: ≥97% (HPLC)
• Forma: film (colorless)
• szín: off-white to beige
• oldhatóság: DMSO: >2 mg/mL
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• SMILES string: C[C@H]1C[C@@H](C)\C=C(C)\C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@H](CC(=O)O1)c4ccc(O)cc4
• InChI: 1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1
• Nemzetközi kémiai azonosító kulcs: GQWYWHOHRVVHAP-DHKPLNAMSA-N

Leírás

Alkalmazás

Jasplakinolide has been used to analyze its influence on sciatic nerve guidance effect in vivo in chicken embryos. It has also been used to apply on the control cells for the treatment for blocking actin dynamics.

Biokémiai/fiziológiai hatások

Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM). In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable