C2618

Cytochalasin D

Ready Made Solution, from Zygosporium mansonii, 5 mg/mL in DMSO

• Szinonimák: Lygosporin A, Zygosporin A
• Tapasztalati képlet (Hill-képlet): C₃₀H₃₇NO₆
• CAS-szám: 22144-77-0
• Molekulatömeg: 507.62
• Beilstein: 1632828
• MDL-szám: MFCD00077706
• UNSPSC kód: 51102829
• PubChem Substance ID: 329775013
• NACRES: NA.85

Tulajdonságok

• biológiai forrás: Zygosporium mansonii
• Minőségi szint: 300
• form: solution
• koncentráció: 5 mg/mL in DMSO
• antibiotikus hatásspektrum: fungi
• Hatásmechanizmus: enzyme | interferes
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• SMILES string: [H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4
• InChI: 1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
• Nemzetközi kémiai azonosító kulcs: SDZRWUKZFQQKKV-JHADDHBZSA-N

Leírás

Alkalmazás

Cytochalasin D are isomeric metabolites of Metarrhizium anisopliae. Cytochalasin D possesses antibiotic and antitumor activity. It also impairs maintenance of long term potentiation (LTP) of actin filaments. It is implicated in promoting conditions favorable for depolymerizing actin.

Biokémiai/fiziológiai hatások

Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.

Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.

Egyéb megjegyzések

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 2
• Lobbanási pont (F): 188.6 °F - closed cup - Solvent
• Lobbanási pont (C): 87 °C - closed cup - Solvent
• Egyéni védőeszköz: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)