A8301
Albumin, glycated human
lyophilized powder
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
human
Minőségi szint
Teszt
90-100% protein basis (biuret)
form
lyophilized powder
a címkézés mértéke
1-5 mol hexose (as fructosamine) per mol albumin
technika/technikák
cell culture | mammalian: suitable
UniProt elérési szám
tárolási hőmérséklet
−20°C
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
Nemzetközi kémiai azonosító kulcs
QYSGYZVSCZSLHT-UHFFFAOYSA-N
Géninformáció
human ... ALB(213)
Általános leírás
Albumin gene is mapped to human chromosome 4q13.3. It is synthesized as a preproalbumin with 609 amino acids in the liver. The mature albumin comprising 585 residues, is generated by the cleavage of signal peptide. Albumin is the major circulating protein in serum. It comprises three domains (I, II and III), each of which is subdivided into two subdomains A and B. A total of six ligand binding site is associated with albumin. Domain IIA and IIIA harbor small heterocyclic or aromatic compounds binding site. Long-chain fatty acid binding sites is present in IB and IIIB domains.
Alkalmazás
Albumin, glycated human has been used:
- as a component of serum-free medium for retinal microglia activation
- to stimulate immortalised proximal tubule epithelial (HK-2) cells for fibronectin production
- as medium supplement in human retinal microvascular endothelial cells (HRMECs) cultures to test its effect on family with sequence similarity 18, member B (FAM18B) expression
Naturally occurring glycated albumin is a sensitive indicator of glycemic control by diabetic patients.
Biokémiai/fiziológiai hatások
Albumin is crucial for physiological processes and is the major transporter for lipids, metal ions and amino acids. It has antioxidant functionality and binds to drugs as well. Mutation in the albumin gene is implicated in an autosomal recessive disorder called Analbuminemia, which is characterized by low levels of albumin. The major glycation site is lysine 525 in albumin. Glycated albumin is a marker of glycemia in diabetes mellitus patients and is useful in assessment of HbA1c based glycemic control.
Fizikai forma
Lyophilized powder containing citrate buffer salts
Elkészítési megjegyzés
Glycated in vitro
Egyéb megjegyzések
View more information on human serum albumin.
Jogi nyilatkozat
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 2
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az ügyfelek ezeket is megtekintették
Glycated albumin is a better glycemic indicator than glycated hemoglobin values in hemodialysis patients with diabetes: effect of anemia and erythropoietin injection
Inaba M, et al.
Journal of the American Society of Nephrology, 18(3), 896-903 (2007)
A novel mutation in the albumin gene (c. 1A> C) resulting in analbuminemia
Caridi G, et al.
European Journal of Clinical Investigation, 43(1), 72-78 (2013)
Role of FAM18B in diabetic retinopathy
Wang AL, et al.
Molecular Vision, 20(1), 1146-1146 (2014)
Stephanie D Burr et al.
Cells, 10(3) (2021-04-04)
Cardiovascular disease, specifically heart failure, is a common complication for individuals with type 2 diabetes mellitus. Heart failure can arise with stiffening of the left ventricle, which can be caused by "active" cardiac fibroblasts (i.e., myofibroblasts) remodeling the extracellular matrix
Mizuho Nakayama et al.
Nature communications, 11(1), 2333-2333 (2020-05-13)
Missense-type mutant p53 plays a tumor-promoting role through gain-of-function (GOF) mechanism. In addition, the loss of wild-type TP53 through loss of heterozygosity (LOH) is widely found in cancer cells. However, malignant progression induced by cooperation of TP53 GOF mutation and
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