8.51095

PyOxim

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Szinonimák: PyOxim, 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
• Tapasztalati képlet (Hill-képlet): C₁₇H₂₉F₆N₅O₃P₂
• CAS-szám: 153433-21-7
• Molekulatömeg: 527.38
• MDL-szám: MFCD18643381
• UNSPSC kód: 12352126
• NACRES: NA.22

Tulajdonságok

• product name: PyOxim, Novabiochem^®
• Minőségi szint: 300
• termékcsalád: Novabiochem^®
• Teszt: ≥99.0% (HPLC)
• form: powder
• reakcióalkalmasság: reaction type: Coupling Reactions
• gyártó/kereskedő neve: Novabiochem^®
• alkalmazás(ok): peptide synthesis
• tárolási hőmérséklet: 15-25°C
• InChI: 1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;
• Nemzetközi kémiai azonosító kulcs: RDWDVLFMPFUBDV-PXMDEAMVSA-N

Leírás

Általános leírás

PyOxim ^[1] is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.

Tulajdonságok és előnyök

• Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
• Mediates coupling with low racemization or epimerization
• Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
• Excellent solubility in DMF and NMP

Analízis megjegyzés

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

Jogi információk

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable