8.51085

COMU

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Szinonimák: COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino)] uronium hexafluorophosphate
• Tapasztalati képlet (Hill-képlet): C₁₂H₁₉F₆N₄O₄P
• CAS-szám: 1075198-30-9
• Molekulatömeg: 428.27
• MDL-szám: MFCD11975052
• UNSPSC kód: 12352107
• NACRES: NA.22

Tulajdonságok

• product name: COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem^®
• Minőségi szint: 300
• termékcsalád: Novabiochem^®
• Teszt: ≥99.0% (HPLC)
• form: powder
• reakcióalkalmasság: reaction type: Coupling Reactions
• gyártó/kereskedő neve: Novabiochem^®
• mp: >140 °C
• alkalmazás(ok): peptide synthesis
• tárolási hőmérséklet: 15-25°C
• InChI: 1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
• Nemzetközi kémiai azonosító kulcs: GPDHNZNLPKYHCN-DZOOLQPHSA-N

Leírás

Általános leírás

COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU ^[1,2].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated ^[3].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404.
^[2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6.
^[3] Jean-d′Amour, et al. (2011) Org. Lett., 13, 2988.

Alkalmazás

• Re-evaluating the stability of COMU in different solvents: This study highlights the robust stability and effectiveness of COMU, promoting its use in various peptide synthesis scenarios, enhancing both scalability and environmental friendliness (Kumar et al., 2017).

Analízis megjegyzés

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (10% in acetonitrile): clear

Jogi információk

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable