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According to literature resources, the solubility of Mitomycin C in phosphate-buffered saline (PBS) is between 0.5 to 1.0 mg/mL depending on the exact ambient temperature.
Összes fotó(1)
Fontos dokumentumok
M0503
Mitomycin C from Streptomyces caespitosus
powder, contains NaCl as solubilizer
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Méret kiválasztása
2 MG
56 900,00 Ft
5 X 2 MG
204 000,00 Ft
10 X 2 MG
361 000,00 Ft
50 X 2 MG
1 290 000,00 Ft
56 900,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Megrendelés igénylése nagy tételben
Összes fotó(1)
Méret kiválasztása
Nézet módosítása
2 MG
56 900,00 Ft
5 X 2 MG
204 000,00 Ft
10 X 2 MG
361 000,00 Ft
50 X 2 MG
1 290 000,00 Ft
About This Item
Tapasztalati képlet (Hill-képlet):
C15H18N4O5
CAS-szám:
Molekulatömeg:
334.33
Beilstein:
7231816
MDL-szám:
UNSPSC kód:
12352207
PubChem Substance ID:
NACRES:
NA.76
56 900,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Megrendelés igénylése nagy tételben
Javasolt termékek
biológiai forrás
Streptomyces caespitosus
Minőségi szint
Forma
powder
tartalmaz
NaCl as solubilizer
szín
gray
purple/blue
(1) 3.2, (2) 6.5
oldhatóság
H2O: 1 vial + 4 mL, clear to slightly hazy, blue to purple
antibiotikus hatásspektrum
Gram-negative bacteria
Gram-positive bacteria
Hatásmechanizmus
DNA synthesis | interferes
tárolási hőmérséklet
2-8°C
SMILES string
[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O
InChI
1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
Nemzetközi kémiai azonosító kulcs
NWIBSHFKIJFRCO-WUDYKRTCSA-N
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Általános leírás
Chemical structure: aziridine
Alkalmazás
Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.
Biokémiai/fiziológiai hatások
Mode of Action: This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5′-CpG-3′. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication.
Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.
Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.
Vigyázat
This vial contains 2 mg Mitomycin C and 48 mg NaCl. Stock solutions should be filter sterilized and stored at 2-8°C in the dark. Solutions at pH 6-9 can be stored at 0-5°C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.
Elkészítési megjegyzés
Mitomycin C is soluble in water at .5 mg/mL, with a pH of 6.0-7.5. It undergoes rapid degradation in acidic solutions with pH<6, and is mostly likely to retain activity in solutions with a pH between 6-9.
Figyelmeztetés
Warning
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Acute Tox. 4 Oral - Carc. 2
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
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Is Mitomycin C, Product M0503, soluble in PBS?
1 answer-
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How do I store a stock solution of Mitomycin C, Product M0503?
1 answer-
Generally, solutions at pH 6-9 can be stored at 0-5 °C for up to a week, and possibly much longer. If a precipitate forms, a fresh solution should be prepared. The precipitated solution has proven to be toxic to cells. A stock solution should also be stored in the dark since mitomycin C is readily decomposed by light. Solutions should not be frozen, since a precipitate is likely to form.
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Why does Mitomycin C, Product M0503, contain NaCl?
1 answer-
Sodium chloride is added to mitomycin C to increase solubility and solution stability.
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What is the difference between Mitomycin C Product No. M0503 and M4287?
1 answer-
The difference between Product Nos. M0503 and M4287 is that Product No. M4287 has been tested on cells. A feeder layer is treated with media containing 10 μg/mL mitomycin C for 3 hours at 37°C to block replication.
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Is Mitomycin C, Product M0503, light sensitive?
1 answer-
Mitomycin C is light sensitive only when in solution and not as a powder.
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How do I use Mitomycin C, Product M0503, to block replication?
1 answer-
Cell functions that require cellular division are abolished by treatment with mitomycin C (causes DNA crosslinking). This can be used to treat cells for feeder layers, for mixed lymphocyte reactions and for removal of fibroblasts from mixed cell cultures. Mitomycin is used at 25 μg/mL to treat cells at 1 - 6 × 107 cells/mL. Cells are treated for 25 minutes at 37 °C. Selected Methods in Cellular Immunology, Michell, BB, and Shiigi, SM, Eds., WH Freeman and Co., New York, 1980, p. 240.
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