42966

12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl)

• Szinonimák: HS 15, Macrogol (15)-hydroxystearate, Polyethylene glycol (15)-hydroxystearate, Polyoxyethylated 12-hydroxystearic acid, Solutol^® HS 15
• CAS-szám: 70142-34-6
• UNSPSC kód: 12161900
• PubChem Substance ID: 329756293
• NACRES: NA.25

Tulajdonságok

• leírás: non-ionic
• Minőségi szint: 100
• form: paste
• összetétel: free macrogoly% (27.0 - 39.0 g/100g (%))
• szennyeződések: acetic acid (≤ 0.5 g/100g (%)); water (≤ 0.5 g/100g (%)); ≤0.05% acetic acid; ≤0.05% water; ≤1 mg/kg ethylene oxide ((ppm)); ≤1 mg/kg ethylene oxide; ≤1 mg/kg nickel ((ppm)); ≤1 mg/kg nickle; ≤10 mg/kg dioxane ((ppm)); ≤10 mg/kg dioxane; ≤10 mg/kg heavy metals; ≤620 mg/kg Diethylene glycol; ≤620 mg/kg diethylene glycol ((ppm)); ≤620 mg/kg ethylene glycol ((ppm)); ≤620 mg/kg ethylene glycol; <10 mg/kg heavy metals ((ppm))
• izzítási maradék: (≤ 0.3 g/100g (%))
• pH: 5.0-7.0 (1 g/10 mL in H₂O)
• mp: 25 - 30 °C (77 - 86 °F)
• savérték: ≤1.0 mg KOH/g
• hidroxil érték: 90‑110 mg KOH/g
• jódérték: ≤2.0 g I₂/100 g
• peroxidérték: ≤3.0 meq/kg
• szappanosítási érték: 53‑63 mg KOH/g
• oldhatóság: water: 200 g/L at 30 °C (86 °F)
• sűrűség: 1.048 g/cm³ at 20 °C (68 °F); 1.03 g/cm³ at 60 °C (140 °F)
• anion nyomok: <1 ppm (Ethylene Oxide); <10 ppm (Dioxane)
• kation nyomok: Ni: <1 ppm; heavy metals: <10 ppm
• alkalmazás(ok): sample preservation
• SMILES string: C(CCCCC(CCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O)CCCCC(=O)O
• InChI: 1S/C47H94O19/c48-15-17-53-19-21-55-23-25-57-27-29-59-31-33-61-35-37-63-39-41-65-43-45-66-44-42-64-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-11-7-6-9-13-46(49)12-8-4-2-1-3-5-10-14-47(50)51/h46,48-49H,1-45H2,(H,50,51)
• Nemzetközi kémiai azonosító kulcs: CYAMZYIUAHNTBO-UHFFFAOYSA-N

Leírás

Általános leírás

12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl), a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).

Alkalmazás

• 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) has been used:
• in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force
• in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses
• to dissolve finerenone for oral application in in vivo-studies

Biokémiai/fiziológiai hatások

12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is mainly used as a solubilizer in parenteral and oral formulations. It is preferred for in vitro screening and in vivo efficacy studies of compounds. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is also used in ophthalmic, macromolecule, suppository, and protein formulations due to its solubilization characteristics and safety profiles. It can form micelles typically ranging from 10-15 nm. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) can be used to develop micro-emulsion IV formulations.

Egyéb megjegyzések

12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is a non-ionic detergent obtained by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxy stearic acid.

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Jogi információk

Solutol is a registered trademark of BASF SE

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H317
• Óvintézkedésre vonatkozó mondatok: P280
• Veszélyességi osztályok: Skin Sens. 1
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): 521.6 °F
• Lobbanási pont (C): 272 °C