P2443

Pluronic^® F-127

powder, BioReagent, suitable for cell culture

• Szinonimák: Non-ionic copolymer surfactant
• Lineáris képlet: (C₃H₆O·C₂H₄O)x
• CAS-szám: 9003-11-6
• MDL-szám: MFCD00082049
• UNSPSC kód: 12161902
• PubChem Substance ID: 24897874
• NACRES: NA.75

Tulajdonságok

• leírás: Non-ionic; contains 100ppm BHT
• Minőségi szint: 200
• termékcsalád: BioReagent
• Forma: powder
• molekulatömeg: ~12600 g/mol
• technika/technikák: cell culture | mammalian: suitable
• CMC: 950-1000 ppm (~25°C)
• átmeneti hőmérséklet: cloud point >100 °C
• HLB (hidrofil/lipofil egyensúly): 18 - 23
• SMILES string: O2C(C2)C.O1CC1
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• Nemzetközi kémiai azonosító kulcs: RVGRUAULSDPKGF-UHFFFAOYSA-N

Leírás

Általános leírás

Pluronicpluronic^® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. It contains polyethylene oxide-polypropylene oxide arranged in a triblock structure to form PEO-PPO-PEO symmetric. Surfactant properties of this polymer derived from its amphiphilic nature, allow them to interact with hydrophobic surfaces and biological membranes.

Alkalmazás

Pluronic^® F-127 has been used:

• as a delivery system for a peptide to the wound site to study the effect of the peptide on wound healing in mice.
• as a surface coating for PDMS (polydimethylsiloxane) stamps to make them hydrogel repellent.
• in the preparation of calcium indicator stock solution for measuring neural activities.
• as a component of phosphate-buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device.
• This non-ionic copolymer surfactant is suitable for use in insect cell culture applications as an antifoaming agent.

Biokémiai/fiziológiai hatások

Pluronic^® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. These properties make this polymer suitable for use as a versatile drug carrier.Pluronic^® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. Additionally, it can promote cellular attachment and collagen formation, which facilitates angiogenesis and tissue regeneration. Due to its efficacy, Pluronic F-127 has been utilized in the encapsulation of mesenchymal stem cells (MSCs) to aid in the regeneration of tissues with low levels of vascularity, such as epithelial tissues, adipose tissues, cartilage, tendons, and bone tissues.

Jogi információk

Pluronic is a registered trademark of BASF

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)