MABN50

Anti-OLIG2 Antibody

mouse monoclonal, 211F1.1

• Szinonimák: oligodendrocyte lineage transcription factor 2, oligodendrocyte-specific bHLH transcription factor 2, human protein kinase C-binding protein RACK17, Protein kinase C-binding protein 2, protein kinase C binding protein 2, Class B basic helix-loop-helix pr
• UNSPSC kód: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Tulajdonságok

• product name: Anti-Olig2 Antibody, clone 211F1.1, clone 211F1.1, from mouse
• biológiai forrás: mouse
• Minőségi szint: 100
• antitest forma: purified immunoglobulin
• klón: 211F1.1, monoclonal
• faj reaktivitás: mouse
• faj reaktivitás (homológia által előrejelzett): rat (based on 100% sequence homology), human (based on 100% sequence homology)
• technika/technikák: immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• izotípus: IgG2aκ
• NCBI elérési szám: NP_005797
• UniProt elérési szám: Q13516
• kiszállítva: wet ice
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... OLIG2(10215)

Leírás

Általános leírás

Oligodendrocyte lineage transcription factor 2 (Olig2) is a protein belonging to group A of the OLIG family of basic helix-loop-helix transcription factors (bHLH). bHLH proteins are divided into 6 groups (A-F), and characterized by their biochemical properties and structure. Olig2 is classified as group A due to its ability to form heterodimers with other bHLH proteins and binding to the E box. Olig2 has a crucial role during development in specifying the final location of motor neurons and oligodendrocytes in the spinal cord, along with the development within the hindbrain of somatic motor neurons. Olig2 expression is observed within oligodendrocytes and in developing astrocytes. Recent studies have shown strong expression of Olig2 in human oligodendrogliomas, primary tumors within the central nervous system, and moderate expression in astrocytomas. These observations have led to the proposal of Olig2 having potential as an oligodendroglioma diagnostic marker.

Egyediség

Anti-Olig2 Antibody recognizes Olig2.

Immunogen

Epitope: Unknown

Recombinant protein corresponding to human Olig2.

Alkalmazás

Detect Olig2 using this Anti-Olig2 Antibody, clone 211F1.1 validated for use in WB, IC, IH & IP.

Immunohistochemistry Analysis: This antibody has been shown to detect Olig2 in coronal brain tissue as reported by an independent laboratory (Cai, J., et al. (2007). Development. 134:1887-1899).

Immunocytochemistry Analysis: This antibody has been shown to detect Olig2, as reported by an independent laboratory (Lee, S.K., et al. (1995). Genes & Dev. 19:282-294).

Immunoprecipitation Analysis: This antibody has been shown to detect Olig2, as reported by an independent laboratory (Lee, S.K., et al. (1995). Genes & Dev. 19:282-294).

Research Category
Neuroscience

Research Sub Category
Neuronal & Glial Markers

Minőség

Evaluated by Western Blot in mouse brain lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected Olig2 on 10 µg of mouse brain lysate.

Cél megnevezése

~37 kDa observed

Fizikai forma

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Tárolás és stabilitás

Stable for 1 year at 2-8°C from date of receipt.

Analízis megjegyzés

Control
Mouse brain lysate

Egyéb megjegyzések

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable