MABN10

Anti-Amyloid β Antibody, clone W0-2

clone WO2, from mouse

• Szinonimák: Alzheimer disease, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Protease nexin-II, amyloid beta (A4) precursor protein, amyloid beta A4 protein, amyloid beta precursor protein, beta-amyloid peptide, human mRNA for amyloid A4 prec
• UNSPSC kód: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• klón: WO2, monoclonal
• application: ELISA; IHC; WB
• faj reaktivitás: mouse, human
• technika/technikák: ELISA: suitable; immunohistochemistry: suitable (paraffin); western blot: suitable
• citations: 47

Tulajdonságok

• biológiai forrás: mouse
• Minőségi szint: 100
• antitest forma: purified immunoglobulin
• klón: WO2, monoclonal
• faj reaktivitás: mouse, human
• technika/technikák: ELISA: suitable; immunohistochemistry: suitable (paraffin); western blot: suitable
• izotípus: IgG2aκ
• NCBI elérési szám: NP_000475
• UniProt elérési szám: P05067
• kiszállítva: wet ice
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... APP(351)

Leírás

Általános leírás

The cerebral and vascular plaques associated with Alzheimer′s disease (AD) are mainly composed of amyloid beta peptides (Aβ). Aβ is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Aβ [1-40], Aβ [1-42], and Aβ [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last APP processing step. Aβ [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. These Amyloid beta antibodies and peptides have been developed as tools for elucidating the biology of AD.

Egyediség

This antibody recognizes amino acid residues 4-10 of human Amyloid β.

Immunogén

Epitope: Amino acid residues 4-10

Human Amyloid β peptide

Alkalmazás

Detect Amyloid β using this Anti-Amyloid β Antibody, clone W0-2 validated for use in WB, IH, ELISA.

Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Amyloid β in Alzheimer’s diseased hippocampus.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Minőség

Evaluated by Western Blot in human Alzheimer disease brain tissue lysate.

Western Blot Analysis: 0.5 µg/ml of this antibody detected Amyloid β in 10 µg of human Alzheimer diseased brain tissue lysate.

Cél megnevezése

Calculated MW is 4 kDa This antibody can also show 120 and 105 kDa APP proteins, and ~45 kDa oligomers of amyloid proteins on our western blot of human Alzheimer diseased brain lysate.

Kapcsolódás

Replaces: MAB1561

Fizikai forma

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Tárolás és stabilitás

Stable for 1 year at 2-8°C from date of receipt.

Analízis megjegyzés

Control
Human Alzheimer diseased brain tissue lysate

Egyéb megjegyzések

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable